Evidence map›Paper›PMID 37635263›Full record

ArticleMolecular autism2023

Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium.

Zachary J Williams, Roseann Schaaf, Karla K Ausderau, Grace T Baranek, D Jonah Barrett, Carissa J Cascio, Rachel L Dumont, Ekomobong E Eyoh, Michelle D Failla, Jacob I Feldman and 23 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 2 countries.

Zachary J Williams *Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA. Zachary.j.williams@vanderbilt.edu.ORCID http://orcid.org/0000-0001-7646-423X
Roseann Schaaf *Department of Occupational Therapy, College of Rehabilitation Sciences, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7132-8212
Karla K AusderauDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-0799-1022
Grace T Baranek *Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5321-6353
D Jonah BarrettNeuroscience Undergraduate Program, Vanderbilt University, Nashville, TN, USA.
Carissa J Cascio *Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-9560-9203
Rachel L DumontDepartment of Occupational Therapy, College of Rehabilitation Sciences, Thomas Jefferson University, Philadelphia, PA, USA.
Ekomobong E EyohInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-1136-5924
Michelle D FaillaCollege of Nursing, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9734-3373
Jacob I FeldmanDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, South Tower, Room 8310, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0002-5723-5834
Jennifer H Foss-FeigSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1491-8248
Heather L Green *Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1213-309X
Shulamite A Green *Department of Psychiatry and Biobehavioral Sciences, University of California - Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4248-3576
Jason L HeDepartment of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2983-0166
Elizabeth A Kaplan-KahnDepartment of Psychology, Syracuse University, Syracuse, NY, USA.ORCID http://orcid.org/0000-0002-2481-3247
Bahar Keçeli-KaysılıDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, South Tower, Room 8310, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0003-2187-2775
Keren MacLennanSchool of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.ORCID http://orcid.org/0000-0002-3148-3450
Zoe Mailloux *Department of Occupational Therapy, College of Rehabilitation Sciences, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7799-6975
Elysa J Marco *Department of Neurodevelopmental Medicine, Cortica Healthcare, San Rafael, CA, USA.ORCID http://orcid.org/0000-0002-5284-9888
Lisa E MashDivision of Psychology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3425-8646
Elizabeth P McKernanDepartment of Psychology, Syracuse University, Syracuse, NY, USA.ORCID http://orcid.org/0000-0002-3001-5794
Sophie MolholmDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-1870-7306
Stewart H MostofskyCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8515-2411
Nicolaas A J Puts *Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1024-1927
Caroline E Robertson *Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.ORCID http://orcid.org/0000-0002-1858-6594
Natalie Russo *Department of Psychology, Syracuse University, Syracuse, NY, USA.ORCID http://orcid.org/0000-0001-5229-3552
Nicole SheaDepartment of Psychology, Syracuse University, Syracuse, NY, USA.
John SiderisMrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7794-3504
James S SutcliffeDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5200-6007
Teresa Tavassoli *School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.ORCID http://orcid.org/0000-0002-7898-2994
Mark T WallaceVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0166-906X
Ericka L Wodka *Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4855-5895
Tiffany G Woynaroski *Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, South Tower, Room 8310, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0001-6513-1181
Vanderbilt University · USChildren's Hospital of Philadelphia · USThomas Jefferson University · USKennedy Krieger Institute · USKing's College London · GBUniversity of Southern California · USAlbert Einstein College of Medicine · USBaylor College of Medicine · USChild Health and Development Institute · USDartmouth College · USDurham University · GBKaleida Health · USNeuroDevelopment Center · USSyracuse University · USThe Ohio State University · USUniversity of California, Los Angeles · USUniversity of Hawaiʻi at Mānoa · USUniversity of Minnesota · USUniversity of Reading · GBUniversity of Wisconsin–Madison · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Peter CM Van Zijl · 2021 to 2026
$9.9M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Neural mechanisms of sensory reactivity and regulation in autism across developmentR01MH124977 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Shulamite Abra Green · 2021 to 2026
$4.4M
Sensorimotor integration governing facial expression production in autism.R01MH102272 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASCIO, CARISSA J · 2014 to 2023
$4.3M
Unusual Sensory Experiences in Young Children w/AutismR01HD042168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARANEK, GRACE T · 2003 to 2012
$4.1M
Sensory Project in Infant/Toddler Siblings of Children with Autism (Project SPIS)R01DC020186 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tiffany Woynaroski · 2022 to 2026
$3.2M
Sensory Integration Therapy in Autism: Mechanisms and EffectivenessR01HD082814 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MOLHOLM, SOPHIE, SCHAAF, ROSEANN C · 2015 to 2019
$3.2M
NIBIB NIH HHS P41 EB031771NICHD NIH HHS P50 HD103537NICHD NIH HHS P50 HD103538NICHD NIH HHS P50 HD105352NICHD NIH HHS R01 HD042168NICHD NIH HHS R01 HD082814NICHD NIH HHS R21 HD100869NICHD NIH HHS U54 HD079123NICHD NIH HHS U54 HD083211NIDCD NIH HHS F30 DC019510NIDCD NIH HHS R01 DC020186NIDCD NIH HHS R21 DC016144NIGMS NIH HHS T32 GM007347NIMH NIH HHS K01 MH090232NIMH NIH HHS K08 MH112871NIMH NIH HHS K23 MH083890NIMH NIH HHS R00 MH107719NIMH NIH HHS R01 MH101536NIMH NIH HHS R01 MH102272NIMH NIH HHS R01 MH124977NIMH NIH HHS R21 MH101321NIMH NIH HHS R21 MH109158
6 · The paper itself

Abstract

backgroundDifferences in responding to sensory stimuli, including sensory hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK) have been observed in autistic individuals across sensory modalities, but few studies have examined the structure of these "supra-modal" traits in the autistic population.

methodsLeveraging a combined sample of 3868 autistic youth drawn from 12 distinct data sources (ages 3-18 years and representing the full range of cognitive ability), the current study used modern psychometric and meta-analytic techniques to interrogate the latent structure and correlates of caregiver-reported HYPER, HYPO, and SEEK within and across sensory modalities. Bifactor statistical indices were used to both evaluate the strength of a "general response pattern" factor for each supra-modal construct and determine the added value of "modality-specific response pattern" scores (e.g., Visual HYPER). Bayesian random-effects integrative data analysis models were used to examine the clinical and demographic correlates of all interpretable HYPER, HYPO, and SEEK (sub)constructs.

resultsAll modality-specific HYPER subconstructs could be reliably and validly measured, whereas certain modality-specific HYPO and SEEK subconstructs were psychometrically inadequate when measured using existing items. Bifactor analyses supported the validity of a supra-modal HYPER construct (ω LIMITATIONS: Conclusions may not be generalizable beyond the specific pool of items used in the current study, which was limited to caregiver report of observable behaviors and excluded multisensory items that reflect many "real-world" sensory experiences.

conclusionOf the three sensory response patterns, only HYPER demonstrated sufficient evidence for valid interpretation at the supra-modal level, whereas supra-modal HYPO/SEEK constructs demonstrated substantial psychometric limitations. For clinicians and researchers seeking to characterize sensory reactivity in autism, modality-specific response pattern scores may represent viable alternatives that overcome many of these limitations.

Indexed as

Autistic DisorderAdolescentBayes TheoremCognitionData AnalysisHumansPhenotypeAutismHyperreactivityHyporeactivityIntegrative data analysisItem response theoryMeasurementMeta-analysisResponsivenessSensitivitySensory featuresSensory seeking

Identifiers

PMID37635263
PMCPMC10464466
OpenAlexW4386209640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.