ArticleEuropean journal of medical research2023
Amoxicillin-induced aseptic meningitis: clinical features, diagnosis and management.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Like father, like daughter: amoxicillin-induced aseptic meningitis in a female patient and her father: a case report.Journal of medical case reports · 2026Article
- A Rare Occurrence of Amoxicillin-Induced Aseptic Meningitis in a Young Adult: A Case Report.Cureus · 2025Article
- Recurrent amoxicillin-induced aseptic meningitis.BMJ case reports · 2025Article
- Antibiotic-induced neuropsychiatric toxicity: epidemiology, mechanisms and management strategies - a narrative literature review.Drugs in context · 2024Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesThe clinical features of aseptic meningitis associated with amoxicillin are unknown. The main objective of this study was to investigate the clinical characteristics of amoxicillin-induced aseptic meningitis (AIAM) and provide a reference for clinical diagnosis and treatment.
methodsAIAM-related studies were collected by searching the relevant databases from inception to October 31, 2022.
resultsAIAM usually occurred 3 h to 7 days after amoxicillin administration in 13 males and 9 females. Twenty-one patients (95.5%) had recurrent AIAM with a total of 62 episodes. Fever (19 cases, 86.4%) and headache (18 cases, 81.8%) were the most common symptoms. Typical cerebrospinal fluid (CSF) findings were leukocytosis (100%) with lymphocytic predominance (14 cases, 63.6%), elevated protein (20 cases, 90.1%), normal glucose (21 cases, 95.5%) and negative culture (21 cases, 100%). Brain magnetic resonance imaging showed mild meningeal enhancement in one patient. The symptoms resolved mainly within 1-4 days after drug discontinuation in all patients.
conclusionClinical attention should be given to the adverse effects of AIAM. The medication history of patients with suspected meningitis should be investigated to avoid unnecessary examination and antibiotic treatment.
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