ArticleJournal of the American Academy of Dermatology2024
Perifollicular linear projections: A dermatoscopic criterion for the diagnosis of lentigo maligna on the face.
Article in Journal of the American Academy of Dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- International Dermoscopy Society consensus recommendations for the management of lentigo maligna.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- Prospective Lesion-Level Analysis of the Inverse Approach for Lentigo Maligna in Real-World Clinical Practice.Dermatology practical & conceptual · 2026Article
- Short Radial Lines Converging on a Common Periadnexal Circle Are Not Exclusive for Facial Lentiginous Melanoma on Sun-Damaged Skin.Dermatology practical & conceptual · 2025Article
- Article
- Expert Consensus on Big Data Collection of Skin and Appendage Disease Phenotypes in Chinese.Phenomics (Cham, Switzerland) · 2024Review
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Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundLentigo maligna (LM) can mimic benign, flat, pigmented lesions and can be challenging to diagnose.
objectiveTo describe a new dermatoscopic feature termed "perifollicular linear projections (PLP)" as a diagnostic criterion for LM on the face.
methodsRetrospective study on reflectance confocal microscopy and dermatoscopy images of flat facial pigmented lesions originating from 2 databases. PLP were defined as short, linear, pigmented projections emanating from hair follicles. Dermatoscopy readers were blinded to the final histopathologic diagnosis.
resultsFrom 83 consecutive LMs, 21/83 (25.3%) displayed "bulging of hair follicles" on reflectance confocal microscopy and 18 of these 21 (85.7%), displayed PLP on dermatoscopy. From a database of 2873 consecutively imaged and biopsied lesions, 252 flat-pigmented facial lesions were included. PLP was seen in 47/76 melanomas (61.8%), compared with 7/176 lesions (3.9%) with other diagnosis (P < .001). The sensitivity was 61.8% (95% CI, 49.9%-72.7%), specificity 96.0% (95% CI, 92.9%-98.4%). PLP was independently associated with LM diagnosis on multivariate analysis (OR 26.1 [95% CI, 9.6%-71.0]). LIMITATIONS: Retrospective study.
conclusionPLP is a newly described dermatoscopic criterion that may add specificity and sensitivity to the early diagnosis of LM located on the face. We postulate that PLP constitutes an intermediary step in the LM progression model.
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