ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2023
Mediterranean-style diet and intracranial large artery stenosis in the Northern Manhattan Study.
Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Dietary Patterns Associated With Risk of Intracranial Atherosclerosis in Older Adults With Hypertension or Myocardial Infarction.Neurology · 2025Article
- Nutritional Barriers to the Adherence to the Mediterranean Diet in Non-Mediterranean Populations.Foods (Basel, Switzerland) · 2024Review
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7 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesGiven Mediterranean-style diet (MeDi) reduces risk of cardiovascular events, we hypothesized MeDi may also be protective against intracranial large artery stenosis (ICAS), a common cause of stroke worldwide.
methodsThis cross-sectional study included stroke-free participants of the Northern Manhattan Study, a diverse population-based study of stroke risk factors. We represented MeDi continuously (range 0-8) based on enrollment food frequency questionnaires, excluding alcohol consumption. We evaluated ICAS both dichotomously at clinically relevant stenosis severities and continuously as a score (possible range 0-44), summated from stenosis severity scores of major intracranial arteries from time-of-flight magnetic resonance angiography. We used logistic or zero-inflated Poisson regression, adjusting for key confounders.
resultsAmong 912 included participants (mean age 64±8 years, 59% female, 65% Hispanic, mean MeDi score 4±1.5), 5% and 8% of participants had ≥50% or ≥70% ICAS, respectively (score median [interquartile range]: 0 [0-2]). Increased MeDi score was inversely associated with ICAS, but did not reach statistical significance (≥50% stenosis odds ratio (OR) [95% confidence interval (CI)]: 0.89 [0.79-1.06]; ≥70% stenosis OR [95% CI]: 0.91 [0.74-1.13]; stenosis score β-estimate [95% CI]: -0.02 [-0.06-0.01]).
conclusionIn this stroke-free subsample, we did not find a significant association between MeDi and ICAS. We may have been limited by statistical power.
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