Evidence map›Paper›PMID 37634218›Full record

ArticleClinical and experimental nephrology2023

Immunological risk and complement genetic evaluations in early onset de novo thrombotic microangiopathy after living donor kidney transplantation: A Japanese multicenter registry.

Nobuhiro Fujiyama, Masayuki Tasaki, Hiroshi Harada, Koichi Tsutahara, Akihiko Matsumoto, Yuji Kamijo, Mariko Toyoda, Daiki Iwami, Masashi Inui, Hiroki Shirakawa and 13 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 16 institutions in 1 country.

Nobuhiro FujiyamaCenter for Kidney Disease and Transplantation, Akita University Hospital, 1-1-1 Hondo, Akita, 010-8543, Japan. fujiyama@hos.akita-u.ac.jp.ORCID http://orcid.org/0000-0001-9411-2254
Masayuki TasakiDivision of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Hiroshi HaradaDepartment of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
Koichi TsutaharaDepartment of Urology, Osaka General Medical Center, Osaka, Japan.
Akihiko MatsumotoDepartment of Urology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Yuji KamijoDepartment of Nephrology, Shinshu University Hospital, Matsumoto, Japan.
Mariko ToyodaDepartment of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Daiki IwamiDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Masashi InuiDepartment of Urology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Chiba, Japan.
Hiroki ShirakawaDepartment of Urology, Ohkubo Hospital, Shinjuku-ku, Tokyo, Japan.
Jun SugimuraDepartment of Urology, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
Mitsuru SaitoDepartment of Urology, Akita University School of Medicine, Akita, Japan.
Kiyohiko HottaDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Masayoshi OkumiDepartment of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kazuhide SaitoDivision of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Yoshihiko WataraiDepartment of Transplant Surgery and Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Aichi, Japan.
Yoshihiko HidakaDepartment of Molecular Genetics, Wakayama Medical University, Wakayama, Japan.
Katsuki OhtaniDepartment of Clinical Nutrition, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Norimitsu InoueDepartment of Molecular Genetics, Wakayama Medical University, Wakayama, Japan.
Nobutaka WakamiyaDepartment of Medicine and Physiology, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Tomonori HabuchiDepartment of Urology, Akita University School of Medicine, Akita, Japan.
Shigeru SatohCenter for Kidney Disease and Transplantation, Akita University Hospital, 1-1-1 Hondo, Akita, 010-8543, Japan.
Japanese Post-kidney Transplant TMA Support Team
Akita University · JPNiigata University · JPRakuno Gakuen University · JPWakayama Medical University · JPHokkaido University · JPIwate Medical University · JPJapanese Red Cross Kumamoto Hospital · JPJapanese Red Cross Nagoya Daini Hospital · JPJichi Medical University · JPKyoto Prefectural University of Medicine · JPOhkubo Hospital · JPOsaka Prefectural Medical Center · JPSapporo City General Hospital · JPShinshu University Hospital · JPThe University of Tokyo · JPTokyo Women's Medical University · JP

Funding

NCCIH NIH HHS No.2017042401
6 · The paper itself

Abstract

backgroundThrombotic microangiopathy (TMA) after kidney transplantation (KTx), particularly early onset de novo (dn) TMA, requires immediate interventions to prevent irreversible organ damage. This multicenter study was performed to investigate the allogeneic clinical factors and complement genetic background of dnTMA after KTx.

methodsPerioperative dnTMA after KTx within 1 week after KTx were diagnosed based on pathological or/and hematological criteria at each center, and their immunological backgrounds were researched. Twelve aHUS-related gene variants were examined in dnTMA cases.

resultsSeventeen recipients (15 donors) were enrolled, and all dnTMA cases were onset within 72-h of KTx, and 16 of 17 cases were ABO incompatible. The implementation rate of pre-transplant plasmaphereses therapies were low, including cases with high titers of anti-A/anti-B antibodies. Examination of aHUS-related gene variants revealed some deletions and variants with minor allele frequency (MAF) in Japan or East Asian genome databases in genes encoding alternative pathways and complement regulatory factors. These variants was positive in 8 cases, 6 of which were positive in both recipient and donor, but only in one graft loss case.

conclusionsAlthough some immunological risks were found for dnTMA after KTx, only a few cases developed into TMA. The characteristic variations revealed in the present study may be novel candidates related to dnTMA in Japanese or Asian patients, but not pathogenic variants of aHUS. Future studies on genetic and antigenic factors are needed to identify factors contributing to dnTMA after KTx.

Indexed as

Kidney TransplantationThrombotic MicroangiopathiesComplement System ProteinsEast Asian PeopleHumansLiving DonorsRetrospective StudiesComplement System ProteinsComplementDe novo TMAImmunological riskKidney transplantationPerioperative period

Identifiers

PMID37634218
OpenAlexW4386203531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.