ArticlePlant communications2024
The haplotype-resolved genome assembly of autotetraploid rhubarb Rheum officinale provides insights into its genome evolution and massive accumulation of anthraquinones.
Article in Plant communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 35 citations in OpenAlex.
- Haplotype-resolved regulation of secondary metabolism in cannabis.Horticulture research · 2026Article
- Haplotype-resolved autotetraploid genome of Dioscorea nipponica provides insights into recent polyploidization, metabolic rewiring, and environmental adaptation.The Plant journal : for cell and molecular biology · 2026Article
- Comparative genomics reveals the evolution of anthraquinone biosynthesis in Polygonaceae.BMC genomics · 2026Article
- Genome-wide analysis of the AP2/ERF gene family in Rheum officinale Baill.: Evolution and expression profiling during plant development, abiotic stresses, and exogenous hormone responses.The plant genome · 2026Article
- Multi-Omics Insights Into Anthraquinone Biosynthesis in Rheum tanguticum.Plant biotechnology journal · 2026Article
- A telomere-to-telomere gap-free genome of the new cultivar 'Zhongtian No. 5', combined with pan-genome analysis, aids in exploration and genetic enhancement of red clover (Horticulture research · 2026Article
- Genome analyses and breeding of polyploid crops.Nature plants · 2025Review
- Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower.International journal of molecular sciences · 2025Review
- Chromosome-level genome assembly assisting for dissecting mechanism of anthocyanin regulation in kiwifruit (Actinidia arguta).Molecular horticulture · 2025Article
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- Genome-wide analysis of MYB transcription factors in fourFrontiers in plant science · 2025Article
- Chromosome-level genome assembly of the tetraploid medicinal and natural dye plant Persicaria tinctoria.Scientific data · 2024Article
- The near-complete genome assembly of hexaploid wild oat reveals its genome evolution and divergence with cultivated oats.Nature plants · 2024Article
- Comparative Analyses of the Complete Mitogenomes of TwoInternational journal of molecular sciences · 2024Article
- T2T genome assemblies of Fallopia multiflora (Heshouwu) and F. multiflora var. angulata.Scientific data · 2024Article
- Multi-Omics Analyses Uncover the Mechanism Underlying Polyploidization-Enhanced Steviol Glycosides Biosynthesis inPlants (Basel, Switzerland) · 2024Article
- Streamlined whole-genome genotyping through NGS-enhanced thermal asymmetric interlaced (TAIL)-PCR.Plant communications · 2024Article
- A genome assembly of decaploidHorticulture research · 2024Article
- A chromosome-level genome assembly and evolutionary analysis of Coregonus ussuriensis Berg.Scientific data · 2024Article
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14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheum officinale, a member of the Polygonaceae family, is an important medicinal plant that is widely used in traditional Chinese medicine. Here, we report a 7.68-Gb chromosome-scale assembly of R. officinale with a contig N50 of 3.47 Mb, which was clustered into 44 chromosomes across four homologous groups. Comparative genomics analysis revealed that transposable elements have made a significant contribution to its genome evolution, gene copy number variation, and gene regulation and expression, particularly of genes involved in metabolite biosynthesis, stress resistance, and root development. We placed the recent autotetraploidization of R. officinale at ∼0.58 mya and analyzed the genomic features of its homologous chromosomes. Although no dominant monoploid genomes were observed at the overall expression level, numerous allele-differentially-expressed genes were identified, mainly with different transposable element insertions in their regulatory regions, suggesting that they functionally diverged after polyploidization. Combining genomics, transcriptomics, and metabolomics, we explored the contributions of gene family amplification and tetraploidization to the abundant anthraquinone production of R. officinale, as well as gene expression patterns and differences in anthraquinone content among tissues. Our report offers unprecedented genomic resources for fundamental research on the autopolyploid herb R. officinale and guidance for polyploid breeding of herbs.
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