Evidence map›Paper›PMID 37633939›Full record

ArticleNature communications2023

Neuronal ER-plasma membrane junctions couple excitation to Ca

Nicholas C Vierra, Luisa Ribeiro-Silva, Michael Kirmiz, Deborah van der List, Pradeep Bhandari, Olivia A Mack, James Carroll, Elodie Le Monnier, Sue A Aicher, Ryuichi Shigemoto and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  8. Signaling architecture of the glucagon-like peptide-1 receptor.The Journal of clinical investigation · 2026
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  14. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Nicholas C VierraDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA, USA. ncvierra@ucdavis.edu.ORCID http://orcid.org/0000-0001-7269-5399
Luisa Ribeiro-SilvaDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA, USA.
Michael KirmizDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA, USA.
Deborah van der ListDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA, USA.
Pradeep BhandariInstitute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.
Olivia A MackChemical Physiology and Biochemistry Department, Oregon Health & Science University, Portland, OR, USA.
James CarrollChemical Physiology and Biochemistry Department, Oregon Health & Science University, Portland, OR, USA.
Elodie Le MonnierInstitute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.
Sue A AicherChemical Physiology and Biochemistry Department, Oregon Health & Science University, Portland, OR, USA.
Ryuichi ShigemotoInstitute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.ORCID http://orcid.org/0000-0001-8761-9444
James S TrimmerDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA, USA. jtrimmer@ucdavis.edu.ORCID http://orcid.org/0000-0002-6117-3912
University of California, Davis · USInstitute of Science and Technology Austria · ATOregon Health & Science University · US

Funding

Neuronal Kv2.1 Potassium Channels as Organizers of Somatic L-Type Calcium Channel MicrodomainsR01NS114210 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES, SANTANA, LUIS F · 2020 to 2024
$2.3M
Defining the Proteomic Composition of ER:Plasma Membrane Junctions in Brain NeuronsR21NS101648 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TRIMMER, JAMES S · 2018 to 2019
$348k
Dynamic modulation of ionic and lipid signaling by neuronal Kv2 channelsF32NS108519 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VIERRA, NICHOLAS CATIN · 2018 to 2020
$168k
NINDS NIH HHS F32 NS108519NINDS NIH HHS R01 NS114210NINDS NIH HHS R21 NS101648
6 · The paper itself

Abstract

Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are specialized membrane contacts ubiquitous in eukaryotic cells. Concentration of intracellular signaling machinery near ER-PM junctions allows these domains to serve critical roles in lipid and Ca

Indexed as

BrainSignal TransductionCell MembraneEndoplasmic ReticulumNeurons

Identifiers

PMID37633939
PMCPMC10460453
OpenAlexW4386190074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.