Evidence map›Paper›PMID 37633932›Full record

ArticleNature communications2023

Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests.

Jérôme Boursier, Marine Roux, Charlotte Costentin, Julien Chaigneau, Céline Fournier-Poizat, Aldo Trylesinski, Clémence M Canivet, Sophie Michalak, Brigitte Le Bail, Valérie Paradis and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. AI-Based Platelet-Independent Noninvasive Test for Liver Fibrosis in MASLD Patients.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Molecular medicine reports · 2024
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 15 institutions in 2 countries.

Jérôme BoursierHepato-Gastroenterology and Digestive Oncology Department, Angers University Hospital, Angers, France. jerome.boursier@univ-angers.fr.ORCID http://orcid.org/0000-0002-7282-1436
Marine RouxHIFIH Laboratory, SFR ICAT 4208, Angers University, Angers, France.
Charlotte CostentinUniv. Grenoble Alpes, Clinique Universitaire d'Hépato-gastroentérologie, CHU Grenoble Alpes, Grenoble, France.
Julien ChaigneauHIFIH Laboratory, SFR ICAT 4208, Angers University, Angers, France.
Céline Fournier-PoizatEchosens, Paris, France.
Aldo TrylesinskiAdvanzPharma, London, UK.
Clémence M CanivetHepato-Gastroenterology and Digestive Oncology Department, Angers University Hospital, Angers, France.
Sophie MichalakHIFIH Laboratory, SFR ICAT 4208, Angers University, Angers, France.
Brigitte Le BailPathology Department, Bordeaux University Hospital, Bordeaux, France.
Valérie ParadisDepartment of Pathology, Physiology and Imaging, Beaujon Hospital Paris Diderot University, Paris, France.
Pierre BedossaDepartment of Pathology, Physiology and Imaging, Beaujon Hospital Paris Diderot University, Paris, France.
Nathalie SturmPathology Department, CHU Grenoble Alpes, Grenoble, France.
Victor de LedinghenBordeaux Institute of Oncology, BRIC UMR U1312, INSERM, Université de Bordeaux, Bordeaux, France.
AFEF group for the study of liver fibrosis
M118 study group
Philip N NewsomeNational Institute for Health Research, Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.ORCID http://orcid.org/0000-0001-6085-3652
Hôpital Cardiologique du Haut-Lévêque · FRUniversity Hospitals Birmingham NHS Foundation Trust · GBCentre National de la Recherche Scientifique · FRUniversité d'Angers · FRUniversité de Bordeaux · FRCentre Hospitalier Universitaire de Grenoble · FRUniversité Paris Cité · FRMundipharma (United Kingdom) · GBNottingham University Hospitals NHS Trust · GBThe Royal Free Hospital · GBAddenbrooke's Hospital · GBBordeaux Population Health · FRJohn Radcliffe Hospital · GBNewcastle University · GBUniversity of Plymouth · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeter

Indexed as

Non-alcoholic Fatty Liver DiseaseAlgorithmsBiopsyCalibrationHumansLiver Cirrhosis

Identifiers

PMID37633932
PMCPMC10460420
OpenAlexW4386194011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.