ArticleBioprocess and biosystems engineering2023
Automated Raman feed-back control of multiple supplemental feeds to enable an intensified high inoculation density fed-batch platform process.
Article in Bioprocess and biosystems engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Raman spectral unmixing for quantitative analysis of multicomponent amino acid mixtures.Analytical and bioanalytical chemistry · 2026Article
- Oxygen-based soft-sensing of glucose demand in Chinese hamster ovary fed-batch cultures across scales.Applied microbiology and biotechnology · 2026Article
- Single compound data supplementation to enhance transferability of fermentation specific Raman spectroscopy models.Analytical and bioanalytical chemistry · 2025Article
- Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins.Bioprocess and biosystems engineering · 2024Article
- Machine learning-assisted clone selection for intensified cell culture processes.Biotechnology progressArticle
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biologics manufacturing is increasingly moving toward intensified processes that require novel control strategies in order to achieve higher titers in shorter periods of time compared to traditional fed-batch cultures. In order to implement these strategies for intensified processes, continuous process monitoring is often required. To this end, inline Raman spectroscopy was used to develop partial least squares models to monitor changes in residual concentrations of glucose, phenylalanine and methionine during the culture of five different glutamine synthetase piggyBac
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Registered trials
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