Evidence map›Paper›PMID 37633258›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024

Clinical Epidemiology and Risk Factors for Critical Outcomes Among Vaccinated and Unvaccinated Adults Hospitalized With COVID-19-VISION Network, 10 States, June 2021-March 2023.

Eric P Griggs, Patrick K Mitchell, Victoria Lazariu, Manjusha Gaglani, Charlene McEvoy, Nicola P Klein, Nimish R Valvi, Stephanie A Irving, Noah Kojima, Edward Stenehjem and 36 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Observational
  7. SARS-CoV-2 uptake and inflammatory response in senescent endothelial cells are regulated by the BSG/VEGFR2 pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
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  12. Review
  13. COVID-19: On the threshold of the fifth year. The situation in Spain.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 14 institutions in 1 country.

Eric P GriggsCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Patrick K MitchellDepartment of Clinical Research, Westat, Inc, Rockville, Maryland, USA.
Victoria LazariuDepartment of Clinical Research, Westat, Inc, Rockville, Maryland, USA.
Manjusha GaglaniSection of Pediatric Infectious Diseases, Department of Pediatrics, Baylor Scott & White Health, Temple, Texas, USA.
Charlene McEvoyDepartment of Research, HealthPartners Institute, Minneapolis, Minnesota, USA.
Nicola P KleinKaiser Permanente Vaccine Study Center, Division of Research, Kaiser Permanente Northern California, Oakland, USA.
Nimish R ValviCenter for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana, USA.
Stephanie A IrvingDepartment of Science Programs, Kaiser Permanente Center for Health Research, Portland, Oregon, USA.
Noah KojimaInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Edward StenehjemDivision of Infectious Diseases and Clinical Epidemiology, Intermountain Healthcare, Salt Lake City, Utah, USA.
Bradley CraneDepartment of Science Programs, Kaiser Permanente Center for Health Research, Portland, Oregon, USA.
Suchitra RaoDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Shaun J GrannisCenter for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana, USA.
Peter J EmbiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Anupam B KharbandaDepartment of Emergency Medicine, Children's Minnesota, Minneapolis, Minnesota, USA.
Toan C OngDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Karthik NatarajanDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York, USA.
Kristin DascombDivision of Infectious Diseases and Clinical Epidemiology, Intermountain Healthcare, Salt Lake City, Utah, USA.
Allison L NalewayDepartment of Science Programs, Kaiser Permanente Center for Health Research, Portland, Oregon, USA.
Elizabeth BassettDepartment of Clinical Research, Westat, Inc, Rockville, Maryland, USA.
Malini B DeSilvaDepartment of Research, HealthPartners Institute, Minneapolis, Minnesota, USA.
Monica DickersonInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Deepika KonathamDepartment of Research Analytics and Development, Baylor Scott & White Research Institute, Baylor Scott & White Health, Temple, Texas, USA.
Bruce FiremanKaiser Permanente Vaccine Study Center, Division of Research, Kaiser Permanente Northern California, Oakland, USA.
Katie S AllenCenter for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana, USA.
Michelle A BarronDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Maura BeatonDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York, USA.
Julie ArndorferDivision of Infectious Diseases and Clinical Epidemiology, Intermountain Healthcare, Salt Lake City, Utah, USA.
Gabriela Vazquez-BenitezDepartment of Research, HealthPartners Institute, Minneapolis, Minnesota, USA.
Shikha GargInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Kempapura MurthyDepartment of Research Analytics and Development, Baylor Scott & White Research Institute, Baylor Scott & White Health, Temple, Texas, USA.
Kristin GoddardKaiser Permanente Vaccine Study Center, Division of Research, Kaiser Permanente Northern California, Oakland, USA.
Brian E DixonCenter for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana, USA.
Jungmi HanDepartment of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York, USA.
Nancy GriselDivision of Infectious Diseases and Clinical Epidemiology, Intermountain Healthcare, Salt Lake City, Utah, USA.
Chandni RaiyaniDepartment of Research Analytics and Development, Baylor Scott & White Research Institute, Baylor Scott & White Health, Temple, Texas, USA.
Ned LewisKaiser Permanente Vaccine Study Center, Division of Research, Kaiser Permanente Northern California, Oakland, USA.
William F FadelCenter for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana, USA.
Melissa S StockwellDivision of Child & Adolescent Health, Department of Pediatrics, New York-Presbyterian Hospital, New York, New York, USA.
Mufaddal MamawalaDepartment of Research Analytics and Development, Baylor Scott & White Research Institute, Baylor Scott & White Health, Temple, Texas, USA.
John HansenKaiser Permanente Vaccine Study Center, Division of Research, Kaiser Permanente Northern California, Oakland, USA.
Ousseny ZerboKaiser Permanente Vaccine Study Center, Division of Research, Kaiser Permanente Northern California, Oakland, USA.
Palak PatelInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ruth Link-GellesCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Katherine AdamsInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Mark W TenfordeInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-8702-8393
Centers for Disease Control and Prevention · USKaiser Permanente · USRegenstrief Institute · USBaylor Scott & White Health · USIntermountain Healthcare · USHealthPartners · USKaiser Permanente Center for Health Research · USUniversity of Colorado Anschutz Medical Campus · USWestat (United States) · USColumbia University Irving Medical Center · USNewYork–Presbyterian Hospital · USChildren's Minnesota · USTemple College · USVanderbilt University Medical Center · US

Funding

CDC HHS 75D30120C07986Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundThe epidemiology of coronavirus disease 2019 (COVID-19) continues to develop with emerging variants, expanding population-level immunity, and advances in clinical care. We describe changes in the clinical epidemiology of COVID-19 hospitalizations and risk factors for critical outcomes over time.

methodsWe included adults aged ≥18 years from 10 states hospitalized with COVID-19 June 2021-March 2023. We evaluated changes in demographics, clinical characteristics, and critical outcomes (intensive care unit admission and/or death) and evaluated critical outcomes risk factors (risk ratios [RRs]), stratified by COVID-19 vaccination status.

resultsA total of 60 488 COVID-19-associated hospitalizations were included in the analysis. Among those hospitalized, median age increased from 60 to 75 years, proportion vaccinated increased from 18.2% to 70.1%, and critical outcomes declined from 24.8% to 19.4% (all P < .001) between the Delta (June-December, 2021) and post-BA.4/BA.5 (September 2022-March 2023) periods. Hospitalization events with critical outcomes had a higher proportion of ≥4 categories of medical condition categories assessed (32.8%) compared to all hospitalizations (23.0%). Critical outcome risk factors were similar for unvaccinated and vaccinated populations; presence of ≥4 medical condition categories was most strongly associated with risk of critical outcomes regardless of vaccine status (unvaccinated: adjusted RR, 2.27 [95% confidence interval {CI}, 2.14-2.41]; vaccinated: adjusted RR, 1.73 [95% CI, 1.56-1.92]) across periods.

conclusionsThe proportion of adults hospitalized with COVID-19 who experienced critical outcomes decreased with time, and median patient age increased with time. Multimorbidity was most strongly associated with critical outcomes.

Indexed as

COVID-19AdolescentAdultAgedCOVID-19 VaccinesHospitalizationHumansImmunity, HerdMiddle AgedRisk FactorsUnvaccinated PersonsCOVID-19 Vaccinesclinical epidemiologyCOVID-19critical diseasedeathhospitalization

Identifiers

PMID37633258
PMCPMC11293024
OpenAlexW4386187512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.