ArticleAsian journal of psychiatry2023
A pilot study to investigate the efficacy and tolerability of lesion network guided transcranial electrical stimulation in outpatients with psychosis spectrum illness.
Article in Asian journal of psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04870710 (Improving Visual Hallucinations by Targeting the Visual Cortex With Electrical Stimulation), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Visual Hallucinations by Targeting the Visual Cortex With Electrical Stimulation: A Feasibility Study
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Research trends and hotspots of post-stroke upper limb dysfunction: a bibliometric and visualization analysis.Frontiers in neurology · 2024Pooled it
- Transcranial alternating current stimulation for neuropsychiatric disorders: a systematic review of treatment parameters and outcomes.Frontiers in psychiatry · 2024Pooled it
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Efficacy and Safety of Transcranial Alternating Current Stimulation Compared to Transcranial Direct Current Stimulation in the Treatment of Psychiatric & Neurological Disorders: A Systematic Review of Head-to-head Trials.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Review
- Efficacy of Transcranial Alternating Current Stimulation (tACS) for Treating Hallucinations: A Systematic Review and Meta-analysis.Indian journal of psychological medicine · 2026Review
- The Therapeutic Effect of High-definition 1-Hz Transcranial Alternating Current Stimulation in PTSD: A Randomized Controlled Trial.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Case Report: Lesion network guided transcranial direct current stimulation targeting treatment refractory hallucinations and delusions: a traditional and accelerated stimulation case study.Frontiers in psychiatry · 2025Article
- Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum.Frontiers in psychiatry · 2025Article
- Lesion network guided neuromodulation to the extrastriate visual cortex in Charles Bonnet syndrome reduces visual hallucinations: A case study.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Lesion network guided delta frequency neuromodulation improves cognition in patients with psychosis spectrum disorders: A pilot study.Asian journal of psychiatry · 2024Article
- A bibliometric analysis of transcranial alternating current stimulation.Frontiers in neuroscience · 2024Article
- Overlap between ophthalmology and psychiatry - A narrative review focused on congenital and inherited conditions.Psychiatry research · 2024Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundTranscranial electrical stimulation (tES) may improve psychosis symptoms, but few investigations have targeted brain regions causally linked to psychosis symptoms. We implemented a novel montage targeting the extrastriate visual cortex (eVC) previously identified by lesion network mapping in the manifestation of visual hallucinations.
objectiveTo determine if lesion network guided High Definition-tES (HD-tES) to the eVC is safe and efficacious in reducing symptoms related to psychosis.
methodsWe conducted a single-blind crossover pilot study (NCT04870710) in patients with psychosis spectrum disorders. Participants first received HD-tDCS (direct current), followed by 4 weeks of wash out, then 2 Hz HD-tACS (alternating current). Participants received 5 days of daily (2×20 min) stimulation bilaterally to the eVC. Primary outcomes included the Positive and Negative Syndrome Scale (PANSS), biological motion task, and Event Related Potentials (ERP) from a steady state visual evoked potential (SSVEP) paradigm. Secondary outcomes included the Montgomery-Asperg Depression Rating Scale, Global Assessment of Functioning (GAF), velocity discrimination and visual working memory task, and emotional ERP.
resultsHD-tDCS improved PANSS general psychopathology in the short-term (d=0.47; p
conclusionLesion network guided HD-tES to the eVC is a safe, efficacious, and promising approach for reducing general psychopathology via changes in neuroplasticity. These results highlight the need for larger clinical trials implementing novel targeting methodologies for the treatments of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.