Evidence map›Paper›PMID 37632511›Full record

ReviewJournal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation2023

Targeting the Gut Microbiota in Kidney Disease: The Future in Renal Nutrition and Metabolism.

Kelly Lambert, Emanuele Rinninella, Annabel Biruete, Keiichi Sumida, Jordan Stanford, Pauline Raoul, Maria Cristina Mele, Angela Yee-Moon Wang, Denise Mafra

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. The Role of Precision Nutrition in Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Microbiota and kidney disease: the road ahead.Nature reviews. Nephrology · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. The role of the intestinal microbiome in cognitive decline in patients with kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 7 countries.

Kelly LambertSchool of Medical, Indigenous, and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia. Electronic address: klambert@uow.edu.au.
Emanuele RinninellaClinical Nutrition Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Annabel BirueteDepartment of Nutrition Science, Purdue University, West Lafayette, Indiana, USA, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana.
Keiichi SumidaDivision of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Tennessee.
Jordan StanfordSchool of Medical, Indigenous, and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, Australia.
Pauline RaoulClinical Nutrition Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Maria Cristina MeleClinical Nutrition Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Angela Yee-Moon WangDepartment of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.
Denise MafraProfessor, Graduate Program in Nutrition Sciences, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Agostino Gemelli University Polyclinic · ITUniversity of Wollongong · AUPurdue University West Lafayette · USQueen Mary Hospital · CNUniversidade Federal Fluminense · BRUniversità Cattolica del Sacro Cuore · ITUniversity of Tennessee Health Science Center · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Translating Measures of Visual Experience to Children with Autism and Down SyndromeKL2TR002530 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI ROBB, SHERI L · 2018 to 2022
$4.8M
NCATS NIH HHS KL2 TR002530NCATS NIH HHS UL1 TR002529
6 · The paper itself

Abstract

There is increasing interest in the therapeutic potential of manipulating the gut microbiome of patients with chronic kidney disease (CKD). This is because there is a substantial deviation from a balanced gut microbiota profile in CKD, with many deleterious downstream effects. Nutritional interventions such as plant-based diets with reduced animal protein intake and the use of probiotics, prebiotics, and synbiotics may alter the microbiome. This article aims to briefly describe what is known about the gut microbiome in patients with CKD, factors contributing to gut dysbiosis, and outline important evidence gaps. Future potential therapies, including restoring the microbiota with food and microbiota-based and metabolomic-based therapies, are also discussed.

Indexed as

Gastrointestinal MicrobiomeProbioticsRenal Insufficiency, ChronicSynbioticsAnimalsHumansKidneyPrebioticsPrebioticschronic kidney diseasedietend-stage kidney diseasegastrointestinalGut microbiomegut microbiotakidney failurenutritionprebioticsprobioticssynbiotics

Identifiers

PMID37632511
PMCPMC10872791
OpenAlexW4386156390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.