Evidence map›Paper›PMID 37632334›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

Determining the effects of elevated partial pressure of oxygen on hypercapnia-induced cerebrovascular reactivity.

Ece Su Sayin, James Duffin, Julien Poublanc, Lashmikumar Venkatraghavan, David John Mikulis, Joseph Arnold Fisher, Olivia Sobczyk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ece Su SayinDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-2419-751X
James DuffinDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Julien PoublancJoint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada.
Lashmikumar VenkatraghavanDepartment of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, ON, Canada.
David John MikulisJoint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada.
Joseph Arnold FisherDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Olivia SobczykDepartment of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evaluation of cerebrovascular reactivity (CVR) to hypo- and hypercapnia is a valuable test for the assessment of vasodilatory reserve. While hypercapnia-induced CVR testing is usually performed at normoxia, mild hyperoxia may increase tolerability of hypercapnia by reducing the ventilatory distress. However, the effects of mild hyperoxia on CVR was unknown. We therefore recruited 21 patients with a range of steno-occlusive diseases and 12 healthy participants who underwent a standardized 13-minute step plus ramp CVR test with a carbon dioxide gas challenge at the subject's resting end-tidal partial pressure of oxygen or at mild hyperoxia (PetO

Indexed as

HypercapniaHyperoxiaBrainCarbon DioxideCerebrovascular CirculationHumansMagnetic Resonance ImagingOxygenPartial PressureCarbon DioxideOxygenCerebrovascular reactivityhypercapniahyperoxiaMRIrepeatability

Identifiers

PMID37632334
PMCPMC10925865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.