Evidence map›Paper›PMID 37632107›Full record

ArticleViruses2023

Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study.

Gregory Morgan, Selina Casalino, Sunakshi Chowdhary, Erika Frangione, Chun Yiu Jordan Fung, Simona Haller, Elisa Lapadula, Mackenzie Scott, Dawit Wolday, Juliet Young and 27 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 9 institutions in 1 country.

Gregory MorganLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-7027-5753
Selina CasalinoLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Sunakshi ChowdharyLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Erika FrangioneLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Chun Yiu Jordan FungLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Simona HallerLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Elisa LapadulaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Mackenzie ScottLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Dawit WoldayLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Juliet YoungLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Saranya ArnoldoDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Navneet AujlaLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Erin BearssMount Sinai Academic Family Health Team, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.
Alexandra BinnieDepartment of Critical Care, William Osler Health System, Etobicoke, ON M9V 1R8, Canada.
Yvonne BombardLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1A6, Canada.
Bjug BorgundvaagSchwartz/Reisman Emergency Medicine Institute, Sinai Health System, Toronto, ON M5G 2A2, Canada.
Laurent BriollaisLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Marc DagherDepartment of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada.
Luke DevineDivision of General Internal Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-5032-3906
Hanna FaghfouryFred A Litwin Family Centre in Genetic Medicine, University Health Network & Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada.
Steven M FriedmanDepartment of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
Lee W GoneauDynacare Medical Laboratories, Brampton, ON L6T 5V1, Canada.
Zeeshan KhanMackenzie Health, Richmond Hill, ON L4C 4Z3, Canada.
Tony MazzulliDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Shelley L McLeodDepartment of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada.
Romina NomigolzarMackenzie Health, Richmond Hill, ON L4C 4Z3, Canada.
Abdul NoorPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Trevor J PughPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada.
David RichardsonWilliam Osler Health System, Brampton, ON L6R 3J7, Canada.
Harpreet Kaur Satnam SinghLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-9535-5781
Jared SimpsonOntario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.
Seth SternMackenzie Health, Richmond Hill, ON L4C 4Z3, Canada.
Lisa StrugThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Ahmed TaherMackenzie Health, Richmond Hill, ON L4C 4Z3, Canada.
Jordan Lerner-EllisLunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.ORCID 0000-0003-3685-5679
Jennifer TaherPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-9377-968X
Mount Sinai Hospital · CAUniversity of Toronto · CAYork Central Hospital · CAOntario Institute for Cancer Research · CAWilliam Osler Health System · CALunenfeld-Tanenbaum Research Institute · CASinai Health System · CASt. Michael's Hospital · CAUniversity Health Network · CA

Funding

CIHR VR4-172753CIHR VS1-175526CIHR VS2-175572
6 · The paper itself

Abstract

The GENCOV study aims to identify patient factors which affect COVID-19 severity and outcomes. Here, we aimed to evaluate patient characteristics, acute symptoms and their persistence, and associations with hospitalization. Participants were recruited at hospital sites across the Greater Toronto Area in Ontario, Canada. Patient-reported demographics, medical history, and COVID-19 symptoms and complications were collected through an intake survey. Regression analyses were performed to identify associations with outcomes including hospitalization and COVID-19 symptoms. In total, 966 responses were obtained from 1106 eligible participants (87% response rate) between November 2020 and May 2022. Increasing continuous age (aOR: 1.05 [95%CI: 1.01-1.08]) and BMI (aOR: 1.17 [95%CI: 1.10-1.24]), non-White/European ethnicity (aOR: 2.72 [95%CI: 1.22-6.05]), hypertension (aOR: 2.78 [95%CI: 1.22-6.34]), and infection by viral variants (aOR: 5.43 [95%CI: 1.45-20.34]) were identified as risk factors for hospitalization. Several symptoms including shortness of breath and fever were found to be more common among inpatients and tended to persist for longer durations following acute illness. Sex, age, ethnicity, BMI, vaccination status, viral strain, and underlying health conditions were associated with developing and having persistent symptoms. By improving our understanding of risk factors for severe COVID-19, our findings may guide COVID-19 patient management strategies by enabling more efficient clinical decision making.

Indexed as

COVID-19HospitalizationHumansInpatientsOntarioRisk Factorsclinical characteristicscomorbiditiesCOVID-19hospitalizationrisk factorsSARS-CoV-2symptoms

Identifiers

PMID37632107
PMCPMC10457914
OpenAlexW4385979497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.