Evidence map›Paper›PMID 37632085›Full record

ArticleViruses2023

The Burden of Epstein-Barr Virus (EBV) and Its Determinants among Adult HIV-Positive Individuals in Ethiopia.

Kidist Zealiyas, Seifegebriel Teshome, Nega Berhe, Wondwossen Amogne, Aklilu Feleke Haile, Ebba Abate, Getnet Yimer, Christoph Weigel, Elshafa Hassan Ahmed, Tamrat Abebe and 1 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kidist ZealiyasAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa 1176, Ethiopia.ORCID 0000-0001-5248-5036
Seifegebriel TeshomeDepartment of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa 9086, Ethiopia.ORCID 0000-0002-3334-522X
Nega BerheAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa 1176, Ethiopia.
Wondwossen AmogneDepartment of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia.ORCID 0000-0002-4950-3966
Aklilu Feleke HaileAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa 1176, Ethiopia.ORCID 0009-0003-1880-1674
Ebba AbateGlobal One Health Initiative, Addis Ababa 1000, Ethiopia.
Getnet YimerCentre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia.
Christoph WeigelComprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Elshafa Hassan AhmedComprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-2525-7123
Tamrat AbebeDepartment of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa 9086, Ethiopia.
Robert BaiocchiComprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Addis Ababa University · ETThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USEthiopian Public Health Institute · ETInternational Trachoma Initiative · ET

Funding

The synergistic contributions of EBV and malaria to the etiology of Burkitt lymphomaR01AI141531 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SAMAYOA REYES, GABRIELA M · 2020 to 2024
$3.6M
NIAID NIH HHS R01 AI141531
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a well-known risk factor for the development of nasopharyngeal carcinoma, Hodgkin's lymphoma (HL), and Non-Hodgkin's lymphoma (NHL). People with HIV infection (PWH) are at increased risk for EBV-associated malignancies such as HL and NHL. Nevertheless, there are limited data on the burden of EBV among this population group in Ethiopia. Hence, this study aimed to determine the burden of EBV infection among adult HIV-positive individuals in Ethiopia and assess the determinants of EBV DNA positivity. We conducted a cross-sectional study at the Tikur Anbessa Specialised Hospital from March 2020 to March 2021. Two hundred and sixty individuals were enrolled in this study, including 179 HIV-positive and 81 HIV-negative individuals. A structured questionnaire was used to capture demographic and individual attributes. In addition, the clinical data of patients were also retrieved from clinical records. EBV viral capsid antigen (VCA) IgG antibody was measured by multiplex flow immunoassay, and EBV DNA levels were tested by quantitative real-time polymerase chain reaction (q-PCR) assays targeting the

Indexed as

Epstein-Barr Virus InfectionsHIV InfectionsHIV SeropositivityHodgkin DiseaseLymphoma, Non-HodgkinNasopharyngeal NeoplasmsAdultAntibodies, ViralCross-Sectional StudiesEthiopiaHerpesvirus 4, HumanHumansImmunoglobulin GAntibodies, ViralImmunoglobulin GDNAEpstein–Barr virusEthiopiaHIV/AIDSviral capsid antigen

Identifiers

PMID37632085
PMCPMC10458830
OpenAlexW4385835359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.