Evidence map›Paper›PMID 37632078›Full record

ReviewViruses2023

Genetic Engineering and Biosynthesis Technology: Keys to Unlocking the Chains of Phage Therapy.

Sixuan Lv, Yuhan Wang, Kaixin Jiang, Xinge Guo, Jing Zhang, Fang Zhou, Qiming Li, Yuan Jiang, Changyong Yang, Tieshan Teng

Abstract readReview
In one paragraph

Review in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Microbiotherapy: an emerging adjunct for burn wound healing.Frontiers in cellular and infection microbiology · 2026
    Review
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sixuan LvSchool of Nursing and Health, Henan University, Kaifeng 475004, China.ORCID 0009-0008-4116-0170
Yuhan WangInstitute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Kaixin JiangSchool of Nursing and Health, Henan University, Kaifeng 475004, China.
Xinge GuoSchool of Nursing and Health, Henan University, Kaifeng 475004, China.
Jing ZhangSchool of Nursing and Health, Henan University, Kaifeng 475004, China.
Fang ZhouSchool of Nursing and Health, Henan University, Kaifeng 475004, China.
Qiming LiSchool of Nursing and Health, Henan University, Kaifeng 475004, China.
Yuan JiangInstitute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Changyong YangSchool of Nursing and Health, Henan University, Kaifeng 475004, China.
Tieshan TengSchool of Nursing and Health, Henan University, Kaifeng 475004, China.ORCID 0000-0002-2150-0261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phages possess the ability to selectively eliminate pathogenic bacteria by recognizing bacterial surface receptors. Since their discovery, phages have been recognized for their potent bactericidal properties, making them a promising alternative to antibiotics in the context of rising antibiotic resistance. However, the rapid emergence of phage-resistant strains (generally involving temperature phage) and the limited host range of most phage strains have hindered their antibacterial efficacy, impeding their full potential. In recent years, advancements in genetic engineering and biosynthesis technology have facilitated the precise engineering of phages, thereby unleashing their potential as a novel source of antibacterial agents. In this review, we present a comprehensive overview of the diverse strategies employed for phage genetic engineering, as well as discuss their benefits and drawbacks in terms of bactericidal effect.

Indexed as

BacteriophagesPhage TherapyAnti-Bacterial AgentsGenetic EngineeringHost SpecificityAnti-Bacterial Agentsantibioticsbiosynthesis technologygenetic engineeringphage therapy

Identifiers

PMID37632078
PMCPMC10457950

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.