Evidence map›Paper›PMID 37632041›Full record

ArticleViruses2023

Molecular and Clinical Epidemiology of SARS-CoV-2 Infection among Vaccinated and Unvaccinated Individuals in a Large Healthcare Organization from New Jersey.

José R Mediavilla, Tara Lozy, Annie Lee, Justine Kim, Veronica W Kan, Elizabeth Titova, Ashish Amin, Michael C Zody, André Corvelo, Dayna M Oschwald and 10 more

Abstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

José R MediavillaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.
Tara LozyCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.ORCID 0000-0002-6478-5690
Annie LeeCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.
Justine KimHackensack Meridian Health Biorepository, Hackensack, NJ 07601, USA.ORCID 0009-0009-6360-2491
Veronica W KanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.
Elizabeth TitovaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.
Ashish AminHackensack Meridian Health Biorepository, Hackensack, NJ 07601, USA.
Michael C ZodyNew York Genome Center, New York, NY 10013, USA.ORCID 0000-0001-6594-7199
André CorveloNew York Genome Center, New York, NY 10013, USA.
Dayna M OschwaldNew York Genome Center, New York, NY 10013, USA.
Amy BaldwinNew York Genome Center, New York, NY 10013, USA.
Samantha FennesseyNew York Genome Center, New York, NY 10013, USA.
Jerry M ZuckermanDepartment of Patient Safety and Quality, Hackensack Meridian Health, Edison, NJ 08837, USA.
Thomas KirnPublic Health and Environmental Laboratories, New Jersey Department of Health, Ewing, NJ 08628, USA.
Liang ChenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.ORCID 0000-0001-5845-2235
Yanan ZhaoCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.ORCID 0000-0002-2664-2795
Kar Fai ChowHackensack Meridian Health Biorepository, Hackensack, NJ 07601, USA.
Tom ManiatisNew York Genome Center, New York, NY 10013, USA.
David S PerlinCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.ORCID 0000-0002-1268-5524
Barry N KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New Jersey was among the first states impacted by the COVID-19 pandemic, with one of the highest overall death rates in the nation. Nevertheless, relatively few reports have been published focusing specifically on New Jersey. Here we report on molecular, clinical, and epidemiologic observations, from the largest healthcare network in the state, in a cohort of vaccinated and unvaccinated individuals with laboratory-confirmed SARS-CoV-2 infection. We conducted molecular surveillance of SARS-CoV-2-positive nasopharyngeal swabs collected in nine hospitals from December 2020 through June 2022, using both whole genome sequencing (WGS) and a real-time RT-PCR screening assay targeting spike protein mutations found in variants of concern (VOCs) within our region. De-identified clinical data were obtained retrospectively, including demographics, COVID-19 vaccination status, ICU admission, ventilator support, mortality, and medical history. Statistical analyses were performed to identify associations between SARS-CoV-2 variants, vaccination status, clinical outcomes, and medical risk factors. A total of 5007 SARS-CoV-2-positive nasopharyngeal swabs were successfully screened and/or sequenced. Variant screening identified three predominant VOCs, including Alpha (

Indexed as

COVID-19Breakthrough InfectionsCOVID-19 VaccinesHumansNew JerseyPandemicsRetrospective StudiesSARS-CoV-2Spike Glycoprotein, CoronavirusCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2breakthroughcomorbidityCOVID-19pandemicRT-PCRSARS-CoV-2sequencingsurveillancevaccinevariants

Identifiers

PMID37632041
PMCPMC10457875

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.