Evidence map›Paper›PMID 37632037›Full record

ArticleViruses2023

Is Slovakia Almost a Hepatitis D Free Country?

Pavol Kristian, Ivana Hockicková, Elena Hatalová, Daniela Žilinčanová, Marek Rác, Veronika Bednárová, Patrícia Denisa Lenártová, Sylvia Dražilová, Ľubomír Skladaný, Ivan Schréter and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Pavol KristianDepartment of Infectology and Travel Medicine, Faculty of Medicine, Louis Pasteur University Hospital, Pavol Jozef Safarik University, 041 90 Kosice, Slovakia.ORCID 0000-0002-4143-1355
Ivana HockickováDepartment of Infectology and Travel Medicine, Faculty of Medicine, Louis Pasteur University Hospital, Pavol Jozef Safarik University, 041 90 Kosice, Slovakia.ORCID 0000-0002-3231-187X
Elena HatalováDepartment of Epidemiology, Faculty of Medicine, Pavol Jozes Safarik University, 040 11 Kosice, Slovakia.ORCID 0000-0003-0929-4642
Daniela ŽilinčanováII. Department of Internal Medicine, HEGITO Division Hepatology, Gastroenterology and Liver Transplantation, F. D. Roosevelt University Hospital, Slovak Medical University, 974 01 Banska Bystrica, Slovakia.
Marek RácDepartment of Internal Medicine, Faculty Hospital, 949 01 Nitra, Slovakia.ORCID 0000-0003-2385-137X
Veronika BednárováDepartment of Epidemiology, Faculty of Medicine, Pavol Jozes Safarik University, 040 11 Kosice, Slovakia.ORCID 0000-0003-0372-4429
Patrícia Denisa LenártováDepartment of Infectology and Travel Medicine, Faculty of Medicine, Louis Pasteur University Hospital, Pavol Jozef Safarik University, 041 90 Kosice, Slovakia.ORCID 0000-0003-4538-0679
Sylvia Dražilová2nd Department of Internal Medicine, Faculty of Medicine, Louis Pasteur University Hospital, Pavol Jozef Safarik University, 041 90 Kosice, Slovakia.ORCID 0000-0003-2448-6757
Ľubomír SkladanýII. Department of Internal Medicine, HEGITO Division Hepatology, Gastroenterology and Liver Transplantation, F. D. Roosevelt University Hospital, Slovak Medical University, 974 01 Banska Bystrica, Slovakia.ORCID 0000-0001-5171-3623
Ivan SchréterDepartment of Infectology and Travel Medicine, Faculty of Medicine, Louis Pasteur University Hospital, Pavol Jozef Safarik University, 041 90 Kosice, Slovakia.ORCID 0009-0007-1271-1300
Peter Jarčuška2nd Department of Internal Medicine, Faculty of Medicine, Louis Pasteur University Hospital, Pavol Jozef Safarik University, 041 90 Kosice, Slovakia.ORCID 0000-0001-6169-9984
Monika HalánováDepartment of Epidemiology, Faculty of Medicine, Pavol Jozes Safarik University, 040 11 Kosice, Slovakia.ORCID 0000-0002-9011-2238
University of Pavol Jozef Šafárik · SKSlovak Medical University · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is assumed that the prevalence of hepatitis D in HBsAg-positive individuals reaches 4.5-13% in the world and on average about 3% in Europe. Data from several European countries, including Slovakia, are missing or are from an older period.

methodsWe analyzed all available data on hepatitis D from Slovakia, including reports from the Slovak Public Health Authority and the results of one prospective study, and three smaller surveys. The determination of anti-HDV IgG and IgM antibodies and/or HDV RNA was used to detect hepatitis D.

resultsIn the years 2005-2022, no confirmed case of acute or chronic HDV infection was reported in Slovakia. The presented survey includes a total of 343 patients, of which 126 were asymptomatic HBsAg carriers, 33 acute hepatitis B, and 184 chronic hepatitis B cases. In a recent prospective study of 206 HBsAg-positive patients who were completely serologically and virologically examined for hepatitis B and D, only 1 anti-HDV IgG-positive and no anti-HDV IgM or HDV RNA-positive cases were detected. In other smaller surveys, two anti-HDV IgG-positive patients were found without the possibility of HDV RNA confirmation. In total, only 3 of 329 HBsAg-positive patients (0.91%) tested positive for anti-HDV IgG antibodies, and none of 220 tested positive for HDV RNA.

conclusionThe available data show that Slovakia is one of the countries with a very low prevalence of HDV infection, reaching less than 1% in HBsAg-positive patients. Routine testing for hepatitis D is lacking in Slovakia, and therefore it is necessary to implement testing of all HBsAg-positive individuals according to international recommendations.

Indexed as

Hepatitis BHepatitis DHepatitis B Surface AntigensHumansImmunoglobulin GImmunoglobulin MPersistent InfectionProspective StudiesSlovakiaHepatitis B Surface AntigensImmunoglobulin GImmunoglobulin Manti-HDV antibodyHDV RNAhepatitis Dprevalence

Identifiers

PMID37632037
PMCPMC10459979
OpenAlexW4385607408

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.