Evidence map›Paper›PMID 37632028›Full record

ArticleViruses2023

The Insertion of an Evolutionary Lost Four-Amino-Acid Cytoplasmic Tail Peptide into a Syncytin-1 Vaccine Increases T- and B-Cell Responses in Mice.

Isabella Skandorff, Jasmin Gille, Emeline Ragonnaud, Anne-Marie Andersson, Silke Schrödel, Christian Thirion, Ralf Wagner, Peter Johannes Holst

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Isabella SkandorffDepartment of Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Jasmin GilleInstitute of Medical Microbiology and Hygiene, Molecular Microbiology, University of Regensburg Germany, 93053 Regensburg, Germany.
Emeline RagonnaudInProTher, COBIS, Ole Maaloesvej 3, 2200 Copenhagen, Denmark.ORCID 0000-0001-5460-7789
Anne-Marie AnderssonInProTher, COBIS, Ole Maaloesvej 3, 2200 Copenhagen, Denmark.
Silke SchrödelSirion Biotech GmbH, Am Haag 6, 82166 Graefelfing, Germany.ORCID 0000-0002-1520-8299
Christian ThirionSirion Biotech GmbH, Am Haag 6, 82166 Graefelfing, Germany.
Ralf WagnerInstitute of Medical Microbiology and Hygiene, Molecular Microbiology, University of Regensburg Germany, 93053 Regensburg, Germany.
Peter Johannes HolstInProTher, COBIS, Ole Maaloesvej 3, 2200 Copenhagen, Denmark.
University of Copenhagen · DKInstitute of Medical Microbiology and Hygiene · DEInprother (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human endogenous retrovirus type W (HERV-W) is expressed in various cancers. We previously developed an adenovirus-vectored cancer vaccine targeting HERV-W by encoding an assembled HERV-W group-specific antigen sequence and the HERV-W envelope sequence Syncytin-1. Syncytin-1 is constitutively fusogenic and forms large multinucleated cell fusions when overexpressed. Consequently, immunising humans with a vaccine encoding Syncytin-1 can lead to the formation of extensive syncytia, which is undesirable and poses a potential safety issue. Here, we show experiments in cell lines that restoring an evolutionary lost cleavage site of the fusion inhibitory R-peptide of Syncytin-1 inhibit cell fusion. Interestingly, this modification of the HERV-W vaccine's fusogenicity increased the expression of the vaccine antigens in vitro. It also enhanced Syncytin-1-specific antibody responses and CD8

Indexed as

Cancer VaccinesEndogenous RetrovirusesPregnancy ProteinsAmino AcidsAnimalsEpitopes, T-LymphocyteGene Products, envHumansMiceAmino AcidsCancer VaccinesEpitopes, T-LymphocyteGene Products, envPregnancy Proteinssyncytinadenoviral vectorcell fusionhuman endogenous retrovirus type W (HERV-W)R-peptideSyncytin-1

Identifiers

PMID37632028
PMCPMC10458386
OpenAlexW4385555581

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.