Evidence map›Paper›PMID 37631980›Full record

ArticleViruses2023

Antiviral Effect of Candies Containing Persimmon-Derived Tannin against SARS-CoV-2 Delta Strain.

Ryutaro Furukawa, Masahiro Kitabatake, Noriko Ouji-Sageshima, Dai Tomita, Makiko Kumamoto, Yuki Suzuki, Akiyo Nakano, Ryuichi Nakano, Yoko Matsumura, Shin-Ichi Kayano and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ryutaro FurukawaDepartment of Immunology, Nara Medical University, Kashihara 6348521, Japan.
Masahiro KitabatakeDepartment of Immunology, Nara Medical University, Kashihara 6348521, Japan.
Noriko Ouji-SageshimaDepartment of Immunology, Nara Medical University, Kashihara 6348521, Japan.
Dai TomitaDepartment of Respiratory & Internal Medicine, National Hospital Organization Nara Medical Center, Nara 6308053, Japan.
Makiko KumamotoDepartment of Respiratory & Internal Medicine, National Hospital Organization Nara Medical Center, Nara 6308053, Japan.
Yuki SuzukiDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara 6348521, Japan.
Akiyo NakanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara 6348521, Japan.ORCID 0000-0003-1379-384X
Ryuichi NakanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara 6348521, Japan.
Yoko MatsumuraDepartment of Immunology, Nara Medical University, Kashihara 6348521, Japan.
Shin-Ichi KayanoDepartment of Health and Nutrition, Faculty of Health Science, Kio University, Koryo 6350832, Japan.
Hisakazu YanoDepartment of Microbiology and Infectious Diseases, Nara Medical University, Kashihara 6348521, Japan.
Shinji TamakiDepartment of Respiratory & Internal Medicine, National Hospital Organization Nara Medical Center, Nara 6308053, Japan.ORCID 0000-0002-7106-6854
Toshihiro ItoDepartment of Immunology, Nara Medical University, Kashihara 6348521, Japan.
Nara Medical University · JPNational Hospital Organization · JPKio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the mouth has the potential to reduce the spread of coronavirus disease 2019 (COVID-19), due to the virus being readily transmitted by dispersed saliva. Persimmon-derived tannin has strong antioxidant and antimicrobial activity owing to its strong adhesion to proteins, and it also exhibited antiviral effects against non-variant and Alpha-variant SARS-CoV-2 in our previous study. In this study, we first demonstrated the antiviral effects of persimmon-derived tannin against the Delta variant of SARS-CoV-2 in vitro via the plaque assay method. We then examined the effects of candy containing persimmon-derived tannin. Remarkably, the saliva samples provided by healthy volunteers while they were eating tannin-containing candy showed that the virus titers of the SARS-CoV-2 Delta variant were suppressed. In addition, we found that the SARS-CoV-2 viral load in saliva from patients with COVID-19 collected immediately after they had eaten the tannin-containing candy was below the level of detection via PCR for SARS-CoV-2. These data suggest that adding persimmon-derived tannin to candy and holding such candy in the mouth is an effective method for inactivating SARS-CoV-2 in saliva, and the application of this approach shows potential for inhibiting the transmission of COVID-19.

Indexed as

COVID-19DiospyrosAntiviral AgentsCandyHumansSARS-CoV-2TanninsAntiviral AgentsTanninsaerosol infectionCOVID-19Delta variantpersimmon-derived tanninsalivaSARS-CoV-2

Identifiers

PMID37631980
PMCPMC10459621
OpenAlexW4385347339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.