Evidence map›Paper›PMID 37631972›Full record

ArticleViruses2023

Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response.

Youwen Zhang, Yulin Xu, Sen Jiang, Shaohua Sun, Jiajia Zhang, Jia Luo, Qi Cao, Wanglong Zheng, François Meurens, Nanhua Chen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Youwen ZhangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yulin XuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Sen JiangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Shaohua SunCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jiajia ZhangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jia LuoCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Qi CaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Wanglong ZhengCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
François MeurensSwine and Poultry Infectious Diseases Research Center, Faculty of Veterinary Medicine, University of Montreal, St. Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0002-0353-4871
Nanhua ChenCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-1909-8760
Jianzhong ZhuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-7082-1993
Yangzhou University · CNUniversity of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) has caused great damage to the global pig industry. Innate immunity plays a significant role in resisting viral infection; however, the exact role of innate immunity in the anti-PEDV response has not been fully elucidated. In this study, we observed that various porcine innate immune signaling adaptors are involved in anti-PEDV (AJ1102-like strain) activity in transfected Vero cells. Among these, TRIF and MAVS showed the strongest anti-PEDV activity. The endogenous TRIF, MAVS, and STING were selected for further examination of anti-PEDV activity. Agonist stimulation experiments showed that TRIF, MAVS, and STING signaling all have obvious anti-PEDV activity. The siRNA knockdown assay showed that TRIF, MAVS, and STING are also all involved in anti-PEDV response, and their remarkable effects on PEDV replication were confirmed in TRIF

Indexed as

Porcine epidemic diarrhea virusAdaptor Proteins, Vesicular TransportAnimalsChlorocebus aethiopsImmunity, InnateRNA, Small InterferingSignal TransductionSwineVero CellsAdaptor Proteins, Vesicular TransportRNA, Small Interferingknockoutpattern recognition receptor (PRR)PEDVporcine innate immunitysignaling adaptorssiRNA

Identifiers

PMID37631972
PMCPMC10458394
OpenAlexW4385309935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.