Evidence map›Paper›PMID 37631945›Full record

ArticleVaccines2023

Efficiency Comparative Approach of Plant-Produced Monoclonal Antibodies against Rabies Virus Infection.

Boonlert Lumlertdacha, Bancha Mahong, Kaewta Rattanapisit, Christine Joy I Bulaon, Thiravat Hemachudha, Waranyoo Phoolcharoen

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Plant-Based Systems for Producing Therapeutic Proteins: Current Status and Future Prospects.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  2. Article
  3. Characterization of plant produced VBiotechnology reports (Amsterdam, Netherlands) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Boonlert LumlertdachaDepartment of Animal Diagnosis and Investigation, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand.
Bancha MahongDepartment of Biological Products, The Government Pharmaceutical Organization, 75/1 Rama VI Rd., Ratchet, Bangkok 10400, Thailand.
Kaewta RattanapisitCenter of Excellence for Plant-Produced Pharmaceuticals, Pharmacognosy and Pharmaceutical Botany Department, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Christine Joy I BulaonCenter of Excellence for Plant-Produced Pharmaceuticals, Pharmacognosy and Pharmaceutical Botany Department, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0009-0003-6736-4132
Thiravat HemachudhaFaculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0001-9480-2247
Waranyoo PhoolcharoenCenter of Excellence for Plant-Produced Pharmaceuticals, Pharmacognosy and Pharmaceutical Botany Department, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0001-5958-7406
Chulalongkorn University · THGovernment of Thailand · THThai Red Cross Society · TH

Funding

The Government Pharmaceutical Organization Thailand N/A
6 · The paper itself

Abstract

Rabies encephalitis is a fatal zoonotic viral disease caused by the neurotropic rabies virus. It remains a major public health concern as it causes almost 100% fatality and has no effective medication after the onset of the disease. However, this illness is preventable with the timely administration of effective post-exposure prophylaxis (PEP) consisting of the rabies vaccine and passive immune globulins (HRIG and ERIG). Recently, conventional PEP has been shown to have many limitations, resulting in little support for these expensive and heterologous globulins. Monoclonal antibody (mAb) production via recombinant technology in animal and human cell cultures, as well as a plant-based platform, was introduced to overcome the costly and high-tech constraints of former preparations. We used transient expression technology to produce two mAbs against the rabies virus in

Indexed as

monoclonal antibodyNicotiana benthamianaplant produced antibody cocktailpost-exposure prophylaxisrabies virus

Identifiers

PMID37631945
PMCPMC10457866
OpenAlexW4385949272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.