Evidence map›Paper›PMID 37631885›Full record

ArticleVaccines2023

The Effect of Previous Exposure to Malaria Infection and Clinical Malaria Episodes on the Immune Response to the Two-Dose Ad26.ZEBOV, MVA-BN-Filo Ebola Vaccine Regimen.

Daniela Manno, Catriona Patterson, Abdoulie Drammeh, Kevin Tetteh, Mattu Tehtor Kroma, Godfrey Tuda Otieno, Bolarinde Joseph Lawal, Seyi Soremekun, Philip Ayieko, Auguste Gaddah and 16 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02509494 (A Staged Phase 3 Study, Including a Double-Blinded Controlled Stage to Evaluate the Safety and Immunogenicity of Ad26.ZEBOV and MVA-BN-Filo as Candidate Prophylactic Vaccines for Ebola), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02509494 phase3completednot on this map

A Staged Phase 3 Study, Including a Double-Blinded Controlled Stage to Evaluate the Safety and Immunogenicity of Ad26.ZEBOV and MVA-BN-Filo as Candidate Prophylactic Vaccines for Ebola

TypeinterventionalSponsorJanssen Vaccines & Prevention B.V.Ran2015 to 2019Enrolled1,023ConditionsEbola Virus DiseaseArmsAd26.ZEBOV, MVA-BN-Filo, MenACWY, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 6 countries.

Daniela MannoLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Catriona PattersonLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Abdoulie DrammehLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Kevin TettehLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Mattu Tehtor KromaEBOVAC Project Office, Kukuna Road, Kambia, Sierra Leone.
Godfrey Tuda OtienoLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Bolarinde Joseph LawalLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Seyi SoremekunLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Philip AyiekoLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Auguste GaddahJanssen Research and Development, 2340 Beerse, Belgium.
Abu Bakarr KamaraEBOVAC Project Office, Kukuna Road, Kambia, Sierra Leone.
Frank BaidenLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Muhammed Olanrewaju AfolabiLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0002-9967-6419
Daniel TindanbilLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Kwabena Owusu-KyeiLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
David IsholaLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Gibrilla Fadlu DeenCollege of Medicine and Allied Health Sciences, University of Sierra Leone, New England Ville, Freetown, Sierra Leone.
Babajide KeshinroJanssen Vaccines and Prevention, 2333 CB Leiden, The Netherlands.ORCID 0000-0003-4673-2955
Yusupha NjieLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Mohamed SamaiCollege of Medicine and Allied Health Sciences, University of Sierra Leone, New England Ville, Freetown, Sierra Leone.
Brett LoweLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Cynthia RobinsonJanssen Vaccines and Prevention, 2333 CB Leiden, The Netherlands.
Bailah LeighCollege of Medicine and Allied Health Sciences, University of Sierra Leone, New England Ville, Freetown, Sierra Leone.
Chris DrakeleyLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Brian GreenwoodLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Deborah Watson-JonesLondon School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
University of London · GBUniversity of Sierra Leone · SLJanssen (Netherlands) · NLJanssen (Belgium) · BE

Funding

Medical Research Council MR/S03286X/1
6 · The paper itself

Abstract

We assessed whether the immunogenicity of the two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen with a 56-day interval between doses was affected by exposure to malaria before dose 1 vaccination and by clinical episodes of malaria in the period immediately after dose 1 and after dose 2 vaccinations. Previous malaria exposure in participants in an Ebola vaccine trial in Sierra Leone (ClinicalTrials.gov: NCT02509494) was classified as low, intermediate, and high according to their antibody responses to a panel of

Indexed as

Ad26.ZEBOVEbolaimmunogenicitymalariaMVA-BN-Filovaccine

Identifiers

PMID37631885
PMCPMC10459393
OpenAlexW4385489957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.