Evidence map›Paper›PMID 37631385›Full record

ArticlePharmaceutics2023

QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency.

Guohui Sun, Peiying Bai, Tengjiao Fan, Lijiao Zhao, Rugang Zhong, R Stanley McElhinney, T Brian H McMurry, Dorothy J Donnelly, Joan E McCormick, Jane Kelly and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Guohui SunBeijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.ORCID 0000-0003-2259-5431
Peiying BaiBeijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Tengjiao FanBeijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Lijiao ZhaoBeijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.ORCID 0000-0002-4876-323X
Rugang ZhongBeijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
R Stanley McElhinneyChemistry Department, Trinity College, D02 PN40 Dublin, Ireland.
T Brian H McMurryChemistry Department, Trinity College, D02 PN40 Dublin, Ireland.
Dorothy J DonnellyChemistry Department, Trinity College, D02 PN40 Dublin, Ireland.
Joan E McCormickChemistry Department, Trinity College, D02 PN40 Dublin, Ireland.
Jane KellyCarcinogenesis Department, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.
Geoffrey P MargisonCarcinogenesis Department, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.ORCID 0009-0001-5471-918X
Beijing University of Technology · CNTrinity College Dublin · IECancer Research UK Manchester Institute · GBUniversity of Manchester · GB

Funding

Beijing Natural Science Foundation 7222016Beijing Science and Technology Plan Z221100007122004National Natural Science Foundation of China 82003599Science and Technology General Project of Beijing Municipal Education Commission KM202110005005the Cancer Research Campaign, Cancer Research UK, the Christie Hospital Trust, Scher-ing-Plough (now Merck & Co), the Irish Cancer Society, the Health Research Board (Ireland), the Leukemia Research Fund, and the European Union Framework 6 programme 037665 CHEMORESthe International Research Cooperation Seed Fund of Beijing University of Technology 2021B41The Project of Cultivation for young top-motch Talents of Beijing Municipal Institutions BPHR202203016
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

inactivating agentsmethyltransferase assayMGMTMGMT activity determinationpseudosubstratesQSARread-across

Identifiers

PMID37631385
PMCPMC10458236
OpenAlexW4386051079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.