Evidence map›Paper›PMID 37631098›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Synthesis, In Silico Log

Boryana Borisova, Hristina Nocheva, Stéphane Gérard, Marie Laronze-Cochard, Stefan Dobrev, Silvia Angelova, Stoyko Petrin, Dancho Danalev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Boryana BorisovaBiotechnology Department, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.
Hristina NochevaDepartment of Physiology and Pathophysiology, Faculty of Medicine, Medical University of Sofia, Sv. Georgi Sofiyski Blvd. 1, 1431 Sofia, Bulgaria.
Stéphane GérardInstitut de Chimie Moléculaire de Reims (ICMR)-UMR CNRS 7312, Université de Reims Champagne-Ardenne, UFR Pharmacie, 51 Rue Cognacq-Jay, 51096 Reims, France.ORCID 0000-0002-8307-9986
Marie Laronze-CochardInstitut de Chimie Moléculaire de Reims (ICMR)-UMR CNRS 7312, Université de Reims Champagne-Ardenne, UFR Pharmacie, 51 Rue Cognacq-Jay, 51096 Reims, France.
Stefan DobrevInstitute of Optical Materials and Technologies "Acad. J. Malinowski", Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 109, 1113 Sofia, Bulgaria.
Silvia AngelovaInstitute of Optical Materials and Technologies "Acad. J. Malinowski", Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 109, 1113 Sofia, Bulgaria.ORCID 0000-0003-4717-8028
Stoyko PetrinBiotechnology Department, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.ORCID 0000-0001-8347-7039
Dancho DanalevBiotechnology Department, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.ORCID 0000-0003-1193-7379
University of Chemical Technology and Metallurgy · BGBulgarian Academy of Sciences · BGCentre National de la Recherche Scientifique · FRMedical University of Sofia · BG

Funding

European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria, project № BG-RRP-2.004-0002, "BiOrgaMCT" project № BG-RRP-2.004-0002, "BiOrgaMCT"
6 · The paper itself

Abstract

backgroundThe inflammatory process represents a specific response of the organism's immune system. More often, it is related to the rising pain in the affected area. Independently of its origin, pain represents a complex and multidimensional acute or chronic subjective unpleasant perception. Currently, medical doctors prescribe various analgesics for pain treatment, but unfortunately, many of them have adverse effects or are not strong enough to suppress the pain. Thus, the search for new pain-relieving medical drugs continues.

methodsNew tetrapeptide analogs of FELL with a generaanalgesic-Glu-X

resultsThe obtained results reveal that Leu is the best choice as a hydrophobic amino acid in the FELL structure.

conclusionsThe best analgesic activity is found in the parent compound FELL and its C-terminal amide analog.

Indexed as

analgesic activityFELL analogspaw-pressure testpeptide synthesis

Identifiers

PMID37631098
PMCPMC10458596
OpenAlexW4386026936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.