ArticlePharmaceuticals (Basel, Switzerland)2023
Combined Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Mesotherapy Protocol to Improve Skin Appearance and Epidermal Barrier Function: A Pilot Study.
Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Efficacy and Safety of Non-Cross-Linked Hyaluronic Acid Mesotherapy for Post-Acne Erythema: A Split-Face, Prospective, Randomized, Single-Center Trial.Journal of cosmetic dermatology · 2026Trial
- Radiofrequency for the Treatment of Facial Ligament Laxity: A Split-face Controlled Exploratory Study.Plastic and reconstructive surgery. Global open · 2026Article
- Clinical and Instrument-Based Evaluation of Plasma IQ Microcurrent Radiofrequency for Periorbital Skin Rejuvenation.Biomedicines · 2026Article
- The Landscape of Radiofrequency Technology for Skin Rejuvenation.Health science reports · 2026Article
- Radiofrequency technology as an anti-aging intervention: clinical efficacy in reversing senescence-driven skin laxity and age-related dermal degeneration.Frontiers in cell and developmental biology · 2026Article
- Decades of Scientific Data and Global Media Reporting on Complications in Non-surgical Aesthetic Treatments for a Transparent Safety Profile: Kissing Snow White Awake.Aesthetic plastic surgery · 2025Article
- International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy: A Multidisciplinary Statement.Journal of clinical medicine · 2025Article
- Integrating VYC-12L With Energy-Based Devices for Skin-Quality Improvement: Global Expert Considerations for Safe and Effective Outcomes.Journal of cosmetic dermatology · 2025Article
- An International Survey on the Use of a Polyrevitalizing Solution With or Without Other Aesthetic Procedures in the Daily Practice of Aesthetic Physicians.Journal of cosmetic dermatology · 2025Article
- Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Comparison of the Efficacy of Two Different Local Anesthesia Techniques for Mesotherapy in Temporal Region Alopecia.Cureus · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-associated changes in epidermal hydration, pigmentation, thickness and cell renewal influence skin appearance and can lead to laxity, dryness and poor skin tone. The aim of this pilot study was to assess the synergistic effects of a new bipolar radiofrequency plus non-crosslinked hyaluronic acid (HA) mesotherapy protocol compared with radiofrequency alone on skin appearance and markers of epidermal function.
methodsThis prospective, single-center, split-face pilot study recruited women aged 25-65 years with dryness and laxity of the facial skin defined by a trans-epidermal water loss (TEWL) value of ≥26 g/m
resultsTwenty female subjects with a mean age of 46 (range 29 to 54) years and dry and lax facial skin were included. TEWL was reduced and skin hydration improved to a greater extent with the combined radiofrequency plus mesotherapy protocol compared with radiofrequency alone (-5.8% vs. +3.9% and +23.1% vs. +1.0%, respectively). The combined protocol was also associated with greater improvements in melanin (-7.5% vs. -1.5%) and erythema values (-7.2% vs. +3.0%), respectively. Ultrasound measures of epidermal thickness and epidermal density were greater after the combined protocol compared with radiofrequency alone (12.0% vs. 5.6% and 57.7% vs. 7.1%, respectively). Both treatments were well-tolerated.
conclusionsThe combined bipolar radiofrequency and HA mesotherapy protocol provided greater improvements in skin hydration, firmness and tone compared with radiofrequency alone. The combination treatment was also associated with greater epidermal thickness and density and increased keratinocyte differentiation suggesting a synergistic effect of both treatments on epidermal homeostasis and barrier function. Both treatments were well-tolerated and led to improvements in facial appearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.