Evidence map›Paper›PMID 37631035›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Design and Synthesis of New Anthranyl Phenylhydrazides: Antileishmanial Activity and Structure-Activity Relationship.

Claudia do Carmo Maquiaveli, Edson Roberto da Silva, Barbara Hild de Jesus, Caio Eduardo Oliveira Monteiro, Tiago Rodrigues Navarro, Luiz Octavio Pereira Branco, Isabela Souza Dos Santos, Nanashara Figueiredo Reis, Arieli Bernardo Portugal, João Luiz Mendes Wanderley and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Evaluation of phenyl hydrazide-based compounds as myeloperoxidase inhibitors.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claudia do Carmo MaquiaveliLaboratório de Farmacologia e Bioquímica (LFBq), Departamento de Medicina Veterinária, Universidade de São Paulo Faculdade de Zootecnia e Engenharia de Alimentos, Av. Duque de Caxias Norte 225, Pirassununga 13635-900, SP, Brazil.
Edson Roberto da SilvaLaboratório de Farmacologia e Bioquímica (LFBq), Departamento de Medicina Veterinária, Universidade de São Paulo Faculdade de Zootecnia e Engenharia de Alimentos, Av. Duque de Caxias Norte 225, Pirassununga 13635-900, SP, Brazil.ORCID 0000-0002-6246-4404
Barbara Hild de JesusLaboratório de Farmacologia e Bioquímica (LFBq), Departamento de Medicina Veterinária, Universidade de São Paulo Faculdade de Zootecnia e Engenharia de Alimentos, Av. Duque de Caxias Norte 225, Pirassununga 13635-900, SP, Brazil.
Caio Eduardo Oliveira MonteiroLaboratório de Farmacologia e Bioquímica (LFBq), Departamento de Medicina Veterinária, Universidade de São Paulo Faculdade de Zootecnia e Engenharia de Alimentos, Av. Duque de Caxias Norte 225, Pirassununga 13635-900, SP, Brazil.
Tiago Rodrigues NavarroLaboratório de Catálise e Síntese de Substâncias Bioativas, Instituto Multidisciplinar de Química, CM UFRJ-Macaé, Universidade Federal do Rio de Janeiro, Macaé CEP 27971-525, RJ, Brazil.
Luiz Octavio Pereira BrancoLaboratório de Catálise e Síntese de Substâncias Bioativas, Instituto Multidisciplinar de Química, CM UFRJ-Macaé, Universidade Federal do Rio de Janeiro, Macaé CEP 27971-525, RJ, Brazil.
Isabela Souza Dos SantosLaboratório de Catálise e Síntese de Substâncias Bioativas, Instituto Multidisciplinar de Química, CM UFRJ-Macaé, Universidade Federal do Rio de Janeiro, Macaé CEP 27971-525, RJ, Brazil.
Nanashara Figueiredo ReisLaboratório de Catálise e Síntese de Substâncias Bioativas, Instituto Multidisciplinar de Química, CM UFRJ-Macaé, Universidade Federal do Rio de Janeiro, Macaé CEP 27971-525, RJ, Brazil.
Arieli Bernardo PortugalLaboratório de Imunoparasitologia, Instituto de Ciências Médicas, Centro Multidisciplinar UFRJ, Macaé CEP 27979-000, RJ, Brazil.
João Luiz Mendes WanderleyLaboratório de Imunoparasitologia, Instituto de Ciências Médicas, Centro Multidisciplinar UFRJ, Macaé CEP 27979-000, RJ, Brazil.
André Borges FariasUnidad Académica de Yucatán, Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Mérida 97302, Yucatán, Mexico.
Nelilma Correia RomeiroIntegrated Laboratory of Scientific Computing (LICC), Federal University of Rio de Janeiro (UFRJ)-Campus Macaé, Aluízio Silva Gomes Avenue 50, Granjas Cavaleiros, Macaé 27930-560, RJ, Brazil.
Evanoel Crizanto de LimaLaboratório de Catálise e Síntese de Substâncias Bioativas, Instituto Multidisciplinar de Química, CM UFRJ-Macaé, Universidade Federal do Rio de Janeiro, Macaé CEP 27971-525, RJ, Brazil.

Funding

São Paulo Research Foundation 2019/23769-4
6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical disease affecting millions of people worldwide. A centenary approach to antimonial-based drugs was first initiated with the synthesis of urea stibamine by Upendranath Brahmachari in 1922. The need for new drug development led to resistance toward antimoniates. New drug development to treat leishmaniasis is urgently needed. In this way, searching for new substances with antileishmanial activity, we synthesized ten anthranyl phenylhydrazide and three quinazolinone derivatives and evaluated them against promastigotes and the intracellular amastigotes of

Indexed as

anthranyl hydrazidesarginaseLeishmaniapolyaminesPTR1

Identifiers

PMID37631035
PMCPMC10458276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.