Evidence map›Paper›PMID 37630788›Full record

ArticleNutrients2023

Evaluation of a New 'Mix-In' Style Glycomacropeptide-Based Protein Substitute for Food and Drinks in Patients with Phenylketonuria and Tyrosinemia.

Marta Delsoglio, Rebecca Capener, Anita MacDonald, Anne Daly, Catherine Ashmore, Sarah Donald, Lisa Gaff, Louise VanDorp, Rachel Skeath, Charlotte Ellerton and 8 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Marta DelsoglioResearch and Innovation, Nutricia Ltd., White Horse Business Park, Trowbridge BA14 0XQ, UK.
Rebecca CapenerResearch and Innovation, Nutricia Ltd., White Horse Business Park, Trowbridge BA14 0XQ, UK.
Anita MacDonaldDietetic Department, Birmingham Children's Hospital, Birmingham B4 6NH, UK.
Anne DalyDietetic Department, Birmingham Children's Hospital, Birmingham B4 6NH, UK.ORCID 0000-0003-2579-8699
Catherine AshmoreDietetic Department, Birmingham Children's Hospital, Birmingham B4 6NH, UK.
Sarah DonaldCambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Lisa GaffCambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Louise VanDorpGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
Rachel SkeathGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
Charlotte EllertonUniversity College London Hospitals NHS Foundation Trust, London WC1N 3BG, UK.
Camille NewbyBristol University Hospitals NHS Foundation Trust, Bristol BS1 3NU, UK.
Georgina DunningBristol University Hospitals NHS Foundation Trust, Bristol BS1 3NU, UK.
Clare DaleQueen Elizabeth Hospital, Birmingham B15 2TH, UK.
Inderdip HunjanBradford Teaching Hospitals, NHS Foundation Trust, Bradford BD5 0NA, UK.
Lucy WhiteSheffield Children's NHS Foundation Trust, Sheffield S10 2TH, UK.
Heather AllenSheffield Children's NHS Foundation Trust, Sheffield S10 2TH, UK.
Gary P HubbardResearch and Innovation, Nutricia Ltd., White Horse Business Park, Trowbridge BA14 0XQ, UK.
Rebecca J StrattonResearch and Innovation, Nutricia Ltd., White Horse Business Park, Trowbridge BA14 0XQ, UK.ORCID 0000-0003-3811-3847
Nutricia (United Kingdom) · GBBirmingham Children's Hospital · GBCambridge University Hospitals NHS Foundation Trust · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBSheffield Children's NHS Foundation Trust · GBUniversity Hospitals Bristol NHS Foundation Trust · GBBradford Teaching Hospitals NHS Foundation Trust · GBQueen Elizabeth Hospital Birmingham · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Nutricia (United Kingdom) NA
6 · The paper itself

Abstract

(1) Background: Poor palatability, large volume, and lack of variety of some liquid and powdered protein substitutes (PSs) for patients with phenylketonuria (PKU) and tyrosinemia (TYR) can result in poor adherence. This study aimed to evaluate a new unflavoured, powdered GMP-based PS designed to be mixed into drinks, foods, or with other PSs, in patients with PKU and TYR. (2) Methods: Paediatric and adult community-based patients were recruited from eight metabolic centres and prescribed ≥1 sachet/day (10 g protein equivalent (PE)) of the Mix-In-style PS over 28 days. Adherence, palatability, GI tolerance, and metabolic control were recorded at baseline and follow-up. Patients who completed at least 7 days of intervention were included in the final analysis. (3) Results: Eighteen patients (3-45 years, nine males) with PKU (

Indexed as

PhenylketonuriasTyrosinemiasAdolescentAdultBeveragesChildChild, PreschoolFemaleFoodGastrointestinal TractGlycopeptidesGlycoproteinsHumansMaleMiddle AgedTreatment OutcomeGlycopeptidesGlycoproteinsglycomacropeptidephenylketonuriaPKUprotein substituteTYRtyrosinemia

Identifiers

PMID37630788
PMCPMC10459832
OpenAlexW4385949237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.