Evidence map›Paper›PMID 37630774›Full record

ArticleNutrients2023

Effects of Quinine on the Glycaemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Females and Males.

Peyman Rezaie, Vida Bitarafan, Braden David Rose, Kylie Lange, Zinat Mohammadpour, Jens Frederik Rehfeld, Michael Horowitz, Christine Feinle-Bisset

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Cellular mechanisms of incretin hormone secretion.Journal of molecular endocrinology · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Peyman RezaieAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Vida BitarafanAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Braden David RoseAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Kylie LangeAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Zinat MohammadpourNutrition, Diabetes and Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia.
Jens Frederik RehfeldDepartment of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Michael HorowitzAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0000-0002-0942-0306
Christine Feinle-BissetAdelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.ORCID 0000-0001-6848-0125
The University of Adelaide · AUSouth Australian Health and Medical Research Institute · AURoyal Adelaide Hospital · AUUniversity of Copenhagen · DK

Funding

National Health and Medical Research Council GNT1103020National Health and Medical Research Council GNT1158296University of Adelaide N/A
6 · The paper itself

Abstract

Intraduodenal quinine, in the dose of 600 mg, stimulates glucagon-like peptide-1 (GLP-1), cholecystokinin and insulin; slows gastric emptying (GE); and lowers post-meal glucose in men. Oral sensitivity to bitter substances may be greater in women than men. We, accordingly, evaluated the dose-related effects of quinine on GE, and the glycaemic responses to, a mixed-nutrient drink in females, and compared the effects of the higher dose with those in males. A total of 13 female and 13 male healthy volunteers received quinine-hydrochloride (600 mg ('QHCl-600') or 300 mg ('QHCl-300', females only) or control ('C'), intraduodenally (10 mL bolus) 30 min before a drink (500 kcal, 74 g carbohydrates). Plasma glucose, insulin,

Indexed as

Gastric EmptyingQuinineBlood GlucoseCholecystokininC-PeptideFemaleGastric Inhibitory PolypeptideGlucagon-Like Peptide 1GlucoseHumansInsulinMaleNutrientsBlood GlucoseCholecystokininC-PeptideGastric Inhibitory PolypeptideGlucagon-Like Peptide 1GlucoseInsulinNutrientsQuininebitter tastegastrointestinal hormonesgut functionshumanpancreatic hormonespostprandial blood glucose

Identifiers

PMID37630774
PMCPMC10459881
OpenAlexW4385839668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.