Evidence map›Paper›PMID 37630512›Full record

ArticleMicroorganisms2023

Use of Monoclonal Antibodies in Pregnant Women Infected by COVID-19: A Case Series.

Pietro Crispino, Raffaella Marocco, Daniela Di Trento, Gloria Guarisco, Blerta Kertusha, Anna Carraro, Sara Corazza, Cristina Pane, Luciano Di Troia, Cosimo Del Borgo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Pietro CrispinoMedicine, Santa Maria Goretti Hospital, Via Scaravelli Snc, 04100 Latina, Italy.ORCID 0000-0002-9793-0794
Raffaella MaroccoUnit of Infectious Disease, Sapienza University of Rome, 04100 Latina, Italy.
Daniela Di TrentoUnit of Infectious Disease, Sapienza University of Rome, 04100 Latina, Italy.
Gloria GuariscoUnit of Diabetology, Santa Maria Goretti Hospital, 04100 Latina, Italy.
Blerta KertushaUnit of Infectious Disease, Sapienza University of Rome, 04100 Latina, Italy.
Anna CarraroUnit of Infectious Disease, Sapienza University of Rome, 04100 Latina, Italy.
Sara CorazzaUnit of Infectious Disease, Sapienza University of Rome, 04100 Latina, Italy.
Cristina PaneUnit of Gynecology, Santa Maria Goretti Hospital, 04100 Latina, Italy.
Luciano Di TroiaUnit of Gynecology, Santa Maria Goretti Hospital, 04100 Latina, Italy.
Cosimo Del BorgoUnit of Infectious Disease, Sapienza University of Rome, 04100 Latina, Italy.
Miriam LichtnerUnit of Infectious Disease, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0002-7730-3953
Sapienza University of Rome · ITOspedale Santa Maria Goretti · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMonoclonal antibodies are designed to target specific proteins of COVID-19 and can be used as a treatment for people with mild to moderate infection and at a high risk of severe disease. Casirivimab/imdevimab, sotrovimab, and Bamlanivimab/etesevimab have been authorized for emergency use in the treatment of COVID-19. However, during pregnancy, these drugs have not been extensively studied.

methodsA total of 22 pregnant women with mild to moderate infection were treated with three different monoclonal antibodies, and efficacy and safety were evaluated in the first period and until six months of follow-up.

resultsNo infusion/allergic reactions occurred. No fatal or adverse events were observed in the pregnant women or fetus. The time of negativization with sotrovimab was shorter in comparison to Imdevimav/casirivimab (

conclusionsPregnant COVID-19 patients receiving sotrovimab obtained better clinical outcomes. Pregnancy or neonatal complications were not observed after monoclonal treatment, confirming the safety and tolerability of these drugs in pregnant women.

Indexed as

COVID-19monoclonal antibody (Mabs)pregnancy

Identifiers

PMID37630512
PMCPMC10459383
OpenAlexW4385421453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.