Evidence map›Paper›PMID 37630459›Full record

ReviewMicroorganisms2023

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products.

Keir Nicholas-Haizelden, Barry Murphy, Michael Hoptroff, Malcolm J Horsburgh

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Phage-Derived Endolysins TargetingAntibiotics (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Hidden Links Between Skin Microbiome and Skin Imaging Phenome.Genomics, proteomics & bioinformatics · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Keir Nicholas-HaizeldenInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 3BX, UK.
Barry MurphyUnilever Research & Development, Port Sunlight, Wirral CH63 3JW, UK.ORCID 0000-0003-2305-5875
Michael HoptroffUnilever Research & Development, Port Sunlight, Wirral CH63 3JW, UK.ORCID 0000-0003-4437-6221
Malcolm J HorsburghInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0002-3806-0039
Unilever (United Kingdom) · GBUniversity of Liverpool · GB

Funding

Biotechnology and Biological Sciences Research Council BB/X511481/1
6 · The paper itself

Abstract

Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions between the host and microbiota facilitated by exploitable effector compounds. Advances in the understanding of microbial colonisation mechanisms alongside species and strain interactions have revealed a novel chemical and biological understanding which displays applicative potential. Studies elucidating the organismal interfaces and concomitant understanding of the central processes of skin biology have begun to unravel a potential wealth of molecules which can exploited for their proposed functions. A variety of skin-microbiome-derived compounds display prospective therapeutic applications, ranging from antioncogenic agents relevant in skin cancer therapy to treatment strategies for antimicrobial-resistant bacterial and fungal infections. Considerable opportunities have emerged for the translation to personal care products, such as topical agents to mitigate various skin conditions such as acne and eczema. Adjacent compound developments have focused on cosmetic applications such as reducing skin ageing and its associated changes to skin properties and the microbiome. The skin microbiome contains a wealth of prospective compounds with therapeutic and commercial applications; however, considerable work is required for the translation of in vitro findings to relevant in vivo models to ensure translatability.

Indexed as

ageingbioprospectinglipidpersonal careskin microbiometherapeutics

Identifiers

PMID37630459
PMCPMC10456854
OpenAlexW4385346146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.