Evidence map›Paper›PMID 37630420›Full record

ArticleMolecules (Basel, Switzerland)2023

Assembling a Cinnamyl Pharmacophore in the C3-Position of Substituted Isatins via Microwave-Assisted Synthesis: Development of a New Class of Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease.

Amritha Manoharan, Jong Min Oh, Feba Benny, Sunil Kumar, Mohamed A Abdelgawad, Mohammed M Ghoneim, Mohamed E Shaker, Mohamed El-Sherbiny, Hailah M Almohaimeed, Prashant Gahtori and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Design, synthesis,RSC advances · 2025
    Article
  8. Combinatorial chemistry & high throughput screening · 2025
    Article
  9. Design, synthesis, andRSC advances · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Amritha ManoharanDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India.
Jong Min OhDepartment of Pharmacy, Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
Feba BennyDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India.
Sunil KumarDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India.
Mohamed A AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0001-9035-5638
Mohammed M GhoneimDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia.ORCID 0000-0002-9179-4373
Mohamed E ShakerDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.
Mohamed El-SherbinyDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh 11597, Saudi Arabia.ORCID 0000-0002-0814-1743
Hailah M AlmohaimeedDepartment of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Prashant GahtoriSchool of Pharmacy, Graphic Era Hill University, Dehradun 248002, India.ORCID 0000-0002-2944-7856
Hoon KimDepartment of Pharmacy, Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.ORCID 0000-0002-7203-3712
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India.
Amrita Vishwa Vidyapeetham · INAlfaisal University · SASunchon National University · KRBeni-Suef University · EGGraphic Era University · INMansoura University · EGPrincess Nourah bint Abdulrahman University · SA

Funding

Indian Council of Social Science Research (ICSSR), India to Bijo Mathew No. 02/90/2022-23/RP/MN
6 · The paper itself

Abstract

Monoamine oxidase (MAO, EC 1.4.3.4) is responsible for the oxidative breakdown of both endogenous and exogenous amines and exists in MAO-A and MAO-B isomers. Eighteen indole-based phenylallylidene derivatives were synthesized via nucleophilic addition reactions comprising three sub-series,

Indexed as

Antipsychotic AgentsIsatinNeuroblastomaParkinson DiseaseDopamine AgentsHumansMicrowavesMolecular Docking SimulationMonoamine OxidasePargylinePharmacophoreAntipsychotic AgentsDopamine AgentsIsatinMonoamine OxidasePargylineindole-based phenylallylidene derivativeskineticsmolecular dockingmonoamine oxidase inhibitorsneurological diseasesneuroprotectionreversibility

Identifiers

PMID37630420
PMCPMC10458360
OpenAlexW4386027142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.