ArticleMolecules (Basel, Switzerland)2023
Binding Specificity of a Novel Cyclo/Maltodextrin-Binding Protein and Its Role in the Cyclodextrin ABC Importer System from Thermoanaerobacterales.
Jorge Aranda-Caraballo, Roberto A Saenz, Alonso A López-Zavala, Beatriz Velazquez-Cruz, Laura Espinosa-Barrera, Yair Cárdenas-Conejo, Andrés Zárate-Romero, Oscar Linares-Vergara, Juan A Osuna-Castro, Edgar Bonales-Alatorre and 2 more
Open access · goldAbstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors at 3 institutions in 1 country.
Jorge Aranda-CaraballoLaboratorio de Biología Sintética, Estructural y Molecular, Universidad de Colima, Carretera Los Limones-Loma de Juárez, Colima 28627, Mexico.
Roberto A SaenzFacultad de Ciencias, Universidad de Colima, Bernal Díaz del Castillo 340, Colima 28045, Mexico.ORCID 0000-0002-0723-2539 Alonso A López-ZavalaDepartamento de Ciencias Químico-Biológicas, Universidad de Sonora, Hermosillo 83000, Mexico.ORCID 0000-0001-9843-3709 Beatriz Velazquez-CruzLaboratorio de Biología Sintética, Estructural y Molecular, Universidad de Colima, Carretera Los Limones-Loma de Juárez, Colima 28627, Mexico.ORCID 0009-0004-9194-0184 Laura Espinosa-BarreraLaboratorio de Biología Sintética, Estructural y Molecular, Universidad de Colima, Carretera Los Limones-Loma de Juárez, Colima 28627, Mexico.
Yair Cárdenas-ConejoConsejo Nacional de Humanidades, Ciencias y Tecnologías, Laboratorio de Biología Sintética, Estructural y Molecular, Universidad de Colima, Carretera Los Limones-Loma de Juárez, Colima 28627, Mexico.
Andrés Zárate-RomeroConsejo Nacional de Humanidades, Ciencias y Tecnologías, Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km 107 CarreteraTijuana-Ensenada, Ensenada 22860, Mexico.ORCID 0000-0002-7723-9250 Oscar Linares-VergaraLaboratorio de Biología Sintética, Estructural y Molecular, Universidad de Colima, Carretera Los Limones-Loma de Juárez, Colima 28627, Mexico.
Juan A Osuna-CastroFacultad de Ciencias Biológicas y Agropecuarias, Universidad de Colima, Autopista Colima-Manzanillo, Tecomán 28100, Mexico.ORCID 0000-0002-4685-5296 Edgar Bonales-AlatorreCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Avenida 25 de julio 965, Colonia Villa de San Sebastián, Colima 28045, Mexico.ORCID 0000-0001-6003-8850 Sara Centeno-LeijaConsejo Nacional de Humanidades, Ciencias y Tecnologías, Laboratorio de Biología Sintética, Estructural y Molecular, Universidad de Colima, Carretera Los Limones-Loma de Juárez, Colima 28627, Mexico.ORCID 0000-0002-8573-4577 Hugo Serrano-PosadaConsejo Nacional de Humanidades, Ciencias y Tecnologías, Laboratorio de Biología Sintética, Estructural y Molecular, Universidad de Colima, Carretera Los Limones-Loma de Juárez, Colima 28627, Mexico.ORCID 0000-0002-7901-475X Universidad de Colima · MXUniversidad de Sonora · MXUniversidad Nacional Autónoma de México · MX
Funding
Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCyT) CB-2018-A1-S-18011, CF-2019-33-549477, INFR-2021-17-316456
6 · The paper itselfAbstract
Extracellular synthesis of functional cyclodextrins (CDs) as intermediates of starch assimilation is a convenient microbial adaptation to sequester substrates, increase the half-life of the carbon source, carry bioactive compounds, and alleviate chemical toxicity through the formation of CD-guest complexes. Bacteria encoding the four steps of the carbohydrate metabolism pathway via cyclodextrins (CM-CD) actively internalize CDs across the microbial membrane via a putative type I ATP-dependent ABC sugar importer system, MdxEFG-(X/MsmX). While the first step of the CM-CD pathway encompasses extracellular starch-active cyclomaltodextrin glucanotransferases (CGTases) to synthesize linear dextrins and CDs, it is the ABC importer system in the second step that is the critical factor in determining which molecules from the CGTase activity will be internalized by the cell. Here, structure-function relationship studies of the cyclo⁄maltodextrin-binding protein MdxE of the MdxEFG-MsmX importer system from
Indexed as
Carrier ProteinsDextrinsBacillotaBacteria, AnaerobicPolysaccharidesStarchThermoanaerobacterCarrier ProteinsDextrinsmaltodextrinPolysaccharidesStarchcarbohydrate metabolismCM-CDMdxESBPstarch-converting pathway
Identifiers
PMID37630332
PMCPMC10458862
OpenAlexW4385873561
What OpenQuestion holds
Textmetadata
LicenceCC BY
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