Structure-Activity Relationship Studies on 6-Chloro-1-phenylbenzazepines Leads to the Identification of a New Dopamine D1 Receptor Antagonist.

Rajan Giri, Hari K Namballa, Vishwashiv Emogaje, Wayne W Harding

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Benzazepines Derivatives: Synthetic Strategy, Structural-Activity Relationships, and Medical Potential as Dopamine and Serotonin Receptor Modulators.ACS omega · 2026
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajan GiriDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10065, USA.

Hari K NamballaDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10065, USA.ORCID 0000-0002-1417-7937

Vishwashiv EmogajeDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10065, USA.

Wayne W HardingDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10065, USA.

Funding

National Institute of Health 1SC1DA049961

6 · The paper itself

Abstract

The 1-phenylbenzazepine template has yielded a number of D1R-like ligands, which, though useful as pharmacological tools, have significant drawbacks in terms of selectivity versus D5R as well as pharmacokinetic behavior. A number of 1-phenylbenzazepines contain a 6-chloro functional group, but extensive SAR studies around the 6-chloro-1-phenylbenzazepine framework have not been reported in the literature. To further understand the tolerance of the 6-chloro-1-phenylbenzazepine template for various substituent groups towards affinity and selectivity at D1R, we synthesized two series of analogs with structural variations at the C-7, C-8,

Indexed as

AmidesReceptors, Dopamine D1BenzazepinesDopamine AntagonistsStructure-Activity Relationship1-phenylbenzazepineAmidesBenzazepinesDopamine AntagonistsReceptors, Dopamine D1antagonistbenzazepineD1RD5Rdopamine

Identifiers

PMID37630262

DOI10.3390/molecules28166010

PMCPMC10458514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.