Evidence map›Paper›PMID 37629638›Full record

ArticleLife (Basel, Switzerland)2023

From In Silico Simulation between TGF-

Terenzio Cosio, Gaetana Costanza, Filadelfo Coniglione, Alice Romeo, Federico Iacovelli, Laura Diluvio, Emi Dika, Ruslana Gaeta Shumak, Piero Rossi, Luca Bianchi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Pharmacotherapy for Keloids and Hypertrophic Scars.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Terenzio CosioPost Graduate School of Microbiology, Immunology, Infectious Diseases, and Transplants (MIMIT), Microbiology Section, Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-4025-7882
Gaetana CostanzaDermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Filadelfo ConiglioneDepartment of Surgical Sciences, University Nostra Signora del Buon Consiglio, 1000 Tirana, Albania.
Alice RomeoDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0001-6162-6814
Federico IacovelliDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0001-7511-6575
Laura DiluvioDermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Emi DikaDermatology, Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna, 40138 Bolog, Italy.ORCID 0000-0003-3186-2861
Ruslana Gaeta ShumakDermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Piero RossiDepartment of Surgical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy.
Luca BianchiDermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-8697-6896
Mattia FalconiDepartment of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.ORCID 0000-0002-3990-4758
Elena CampioneDermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
University of Rome Tor Vergata · ITAzienda USL di Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Objective: Keloid and hypertrophic scars are a challenge in clinical management, causing functional and psychological discomfort. These pathological scars are caused by a proliferation of dermal tissue following skin injury. The TGF-β/Smad signal pathway in the fibroblasts and myofibroblasts is involved in the scarring process of skin fibrosis. Today, multiple therapeutic strategies that target the TGF-β/Smad signal pathway are evaluated to attenuate aberrant skin scars that are sometimes difficult to manage. We performed a head-to-head, randomized controlled trial evaluating the appearance of the post-surgical scars of 64 subjects after two times daily topical application to compare the effect of a class I pullulan-based medical device containing

Indexed as

Allium cepahyaluronic acidmedical devicemolecular dockingpullulanquercetinscarsilicone gel

Identifiers

PMID37629638
PMCPMC10455185
OpenAlexW4386028758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.