Evidence map›Paper›PMID 37629556›Full record

ArticleLife (Basel, Switzerland)2023

Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients.

Marko Lucijanic, Ida Tjesic-Drinkovic, Nevenka Piskac Zivkovic, Frane Pastrovic, Zrinka Rob, Mersiha Bacevac, Martina Sedinic Lacko, Eleonora Dzambas, Barbara Medic, Ivan Vukoja and 4 more

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Thromboembolic Events in the Era of COVID-19: A Detailed Narrative Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marko LucijanicHematology Department, University Hospital Dubrava, 10000 Zagreb, Croatia.ORCID 0000-0002-1372-2040
Ida Tjesic-DrinkovicDepartment of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, 10000 Zagreb, Croatia.
Nevenka Piskac ZivkovicPulmonology Department, University Hospital Dubrava, 10000 Zagreb, Croatia.ORCID 0000-0001-5377-0269
Frane PastrovicDepartment of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, 10000 Zagreb, Croatia.ORCID 0000-0002-8467-3733
Zrinka RobDepartment of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, 10000 Zagreb, Croatia.
Mersiha BacevacDepartment of Emergency and Intensive Care Medicine, University Hospital Dubrava, 10000 Zagreb, Croatia.ORCID 0009-0006-7554-0927
Martina Sedinic LackoHematology Department, University Hospital Dubrava, 10000 Zagreb, Croatia.
Eleonora DzambasDepartment of Emergency and Intensive Care Medicine, University Hospital Dubrava, 10000 Zagreb, Croatia.
Barbara MedicDepartment of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, 10000 Zagreb, Croatia.
Ivan VukojaGastroenterology and Nephrology Department, General County Hospital Pozega, 34000 Pozega, Croatia.ORCID 0000-0002-2417-1811
Iva BusicSchool of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-5552-1984
Ivica GrgurevicSchool of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0003-0520-3483
Ivica LuksicSchool of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-9138-2037
Bruno BarsicSchool of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thromboprophylaxis is a mainstay of treatment of hospitalized COVID-19 patients, due to the high occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated a cohort of 4014 consecutively hospitalized COVID-19 patients treated in a tertiary-level institution in the period 3/2020-3/2021. Bleeding of any kind was documented in 322 (8%) and major bleeding in 129 (3.2%) patients. A total of 129 (40.1%) bleeding events were present at the time of hospital admission, and 193 (59.9%) occurred during hospitalization. In the multivariate logistic regression analysis, intensive-care-unit treatment (adjusted odds ratio (aOR) 6.55;

Indexed as

coagulopathyIL-6low molecular weight heparinSARS-CoV-2thrombo-inflammation

Identifiers

PMID37629556
PMCPMC10455881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.