The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases.

Yu Meng, Cheryl Ingram-Smith, Oly Ahmed, Kerry Smith

Open access · goldAbstract read

In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 87% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yu MengDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.

Cheryl Ingram-SmithDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.

Oly AhmedDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0003-4627-4050

Kerry SmithDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA.

Clemson University · USWenzhou-Kean University · CN

Funding

Acetate and ATP binding in acetyl-CoA synthetaseR15GM069374 · NIGMS · CLEMSON UNIVERSITY · PI SMITH, KERRY SCOT · 2004 to 2004

$221k

NIGMS NIH HHS R15 GM069374NIH HHS GM69374-01A1

6 · The paper itself

Abstract

Short- and medium-chain acyl-CoA synthetases catalyze similar two-step reactions in which acyl substrate and ATP bind to form an enzyme-bound acyl-adenylate, then CoA binds for formation of the acyl-CoA product. We investigated the roles of active site residues in CoA binding in acetyl-CoA synthetase (Acs) and a medium-chain acyl-CoA synthetase (Macs) that uses 2-methylbutyryl-CoA. Three highly conserved residues, Arg

Indexed as

acetyl-CoAacetyl-CoA synthetaseacyl-CoA synthetasecoenzyme Amethanoarchaea

Identifiers

PMID37629500

DOI10.3390/life13081643

PMCPMC10455477

OpenAlexW4385350252

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.