ArticleJournal of clinical medicine2023
Impact of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome during Intensive Care Admission on Each Post-Intensive Care Syndrome Component in a PICS Clinic.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Epidemiological characteristics, SAP-associated sepsis, and prognostic analysis of persistent inflammation- immunosuppression-catabolism syndrome in severe acute pancreatitis patients after percutaneous drainage: a retrospective study.Frontiers in cell and developmental biology · 2026Article
- Proposing a novel ABCDEF framework for managing critical illness in geriatrics: challenges and perspectives.Annals of medicine · 2025Article
- LASSO-Based Machine Learning Algorithm for Prediction of PICS Associated with Sepsis.Infection and drug resistance · 2024Article
- Early Oral/Enteral Feeding and Rehabilitation Are Associated With Lower PIICS Incidence: A Propensity Score-Matched Single Center Study.Acute medicine & surgeryArticle
- Post-intensive care syndrome: Recent advances and future directions.Acute medicine & surgeryReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is known as a prolonged immunodeficiency that occurs after severe infection. Few studies have demonstrated a direct relationship between PIICS and physical dysfunction in post-intensive care syndrome (PICS). We herein investigated how each component of PICS was affected by the diagnosis of PIICS during hospitalization and examined the relationship between PIICS and PICS using PICS assessments performed at the Hitachi General Hospital PICS Clinic.
methodsThe 273 patients who visited the PICS clinic at one month after discharge from the ICU at Hitachi General Hospital were included in the study. We used the diagnostic criteria for PIICS described in previous studies. At least two of the following blood test values on day 14 of hospitalization had to be met for a diagnosis of PIICS: C-reactive protein (CRP) > 2.0 mg/dL, albumin (Alb) < 3.0 g/dL, and lymphocytes (Lym) < 800/μL. Blood test values closest to day 14 out of 11-17 days of hospitalization were used. The primary outcome was a Barthel Index (BI) < 90, while secondary outcomes were the results of various PICS assessments, including mental and cognitive impairments, performed at the PICS clinic. We supplemented missing data with multiple imputations by chained equations. We performed a nominal logistic regression analysis with age, sex, BMI, SOFA, and the presence of PIICS as variables for BI < 90.
resultsForty-three out of two hundred seventy-three PICS outpatients met the diagnostic criteria for PIICS during hospitalization. In comparisons with non-PIICS patients, significantly higher severity scores for APACHE II and SOFA and a longer hospital stay were observed in PIICS patients, suggesting a higher clinical severity. The primary outcome, BI, was lower in the PIICS group (97.5 (58.5, 100) vs. 100 (95, 100),
conclusionsThe present study revealed a strong relationship between PIICS and post-discharge PICS physical dysfunction in patients requiring intensive care.
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