Evidence map›Paper›PMID 37629457›Full record

ArticleJournal of clinical medicine2023

Adverse Outcome Following Mild Traumatic Brain Injury Is Associated with Microstructure Alterations at the Gray and White Matter Boundary.

Lara Pankatz, Philine Rojczyk, Johanna Seitz-Holland, Sylvain Bouix, Leonard B Jung, Tim L T Wiegand, Elena M Bonke, Nico Sollmann, Elisabeth Kaufmann, Holly Carrington and 11 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Lara PankatzPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Philine RojczykPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.ORCID 0000-0002-9813-3690
Johanna Seitz-HollandPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Sylvain BouixPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.ORCID 0000-0003-1326-6054
Leonard B JungPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Tim L T WiegandPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Elena M BonkePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Nico SollmannPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.ORCID 0000-0002-8120-2223
Elisabeth KaufmannPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Holly CarringtonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Twishi PuriPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Yogesh RathiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Michael J ColemanPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Mark S GeorgePsychiatry Department, Medical University of South Carolina, Charleston, SC 29425, USA.
Thomas W McAllisterDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Ross ZafonteDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9564-2871
Christine E MarxVA Mid-Atlantic Mental Illness Research and Clinical Center (MIRECC) and Durham VA Medical Center, Durham, NC 27705, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Inga K KoertePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA 02145, USA.
Brigham and Women's Hospital · USDuke University · USIndiana University School of MedicineMedical University of South Carolina · USUniversity of California San Diego · US

Funding

SGM Administrative SupplementR01NS115957 · NINDS · RBHS-SCHOOL/ HEALTH RELATED PROFESSIONS · PI ESOPENKO, CARRIE LYNN, HILLARY, FRANK GERARD · 2021 to 2025
$3.4M
Sex Differences in Brain Structure and Function After Sports-Related ConcussionR01NS100952 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KOERTE, INGA KATHARINA · 2017 to 2022
$2.9M
CRCNS:Subject-Specific Difusion MRI Profiles of Injury in TBI and PTSDR01HD090641 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN · 2016 to 2018
$810k
European Research Council ERC Starting Grant 804326NIH HHS R01 HD090641NIH HHS R01 NS100952NIH HHS R01 NS115957
6 · The paper itself

Abstract

The gray matter/white matter (GM/WM) boundary of the brain is vulnerable to shear strain associated with mild traumatic brain injury (mTBI). It is, however, unknown whether GM/WM microstructure is associated with long-term outcomes following mTBI. The diffusion and structural MRI data of 278 participants between 18 and 65 years of age with and without military background from the Department of Defense INTRuST study were analyzed. Fractional anisotropy (FA) was extracted at the GM/WM boundary across the brain and for each lobe. Additionally, two conventional analytic approaches were used: whole-brain deep WM FA (TBSS) and whole-brain cortical thickness (FreeSurfer). ANCOVAs were applied to assess differences between the mTBI cohort (

Indexed as

cognitive impairmentdiffusion tensor imagingfractional anisotropymagnetic resonance imagingmild traumatic brain injurypost-concussion symptoms

Identifiers

PMID37629457
PMCPMC10455493
OpenAlexW4386026868

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.