Evidence map›Paper›PMID 37629420›Full record

ArticleJournal of clinical medicine2023

Depression and Anxiety in Association with Polypharmacy in Patients with Multiple Sclerosis.

Julia Baldt, Niklas Frahm, Michael Hecker, Barbara Streckenbach, Silvan Elias Langhorst, Pegah Mashhadiakbar, Katja Burian, Janina Meißner, Felicita Heidler, Jörg Richter and 1 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia BaldtSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.
Niklas FrahmSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.
Michael HeckerSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.ORCID 0000-0001-7015-3094
Barbara StreckenbachSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.
Silvan Elias LanghorstSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.ORCID 0000-0001-8286-693X
Pegah MashhadiakbarSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.
Katja BurianSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.
Janina MeißnerSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.
Felicita HeidlerEcumenic Hainich Hospital GmbH, 99974 Mühlhausen, Germany.
Jörg RichterEcumenic Hainich Hospital GmbH, 99974 Mühlhausen, Germany.
Uwe Klaus ZettlSection of Neuroimmunology, Department of Neurology, Rostock University Medical Centre, 18147 Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polypharmacy (intake of ≥5 drugs) is an important issue for patients with chronic diseases such as multiple sclerosis (MS). We aimed to assess the prevalence of polypharmacy with regard to the severity of anxiety/depression and to comorbidities. Therefore, 374 MS patients from two German neurological sites were examined for drug burden, comorbidities, disability level and psychopathological measures capturing depression and anxiety using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D). We found that patients with a higher HADS-D score take more medication (r = 0.217,

Indexed as

anxietycomorbiditydepressionmultiple sclerosispolypharmacytherapy switches

Identifiers

PMID37629420
PMCPMC10456074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.