ReviewInternational journal of molecular sciences2023
Periodontal Disease and Its Association with Metabolic Syndrome-A Comprehensive Review.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Root Cementum Molecular Structure and Its Role in Maintaining Oral Health-Systematic Review.International journal of molecular sciences · 2025Pooled it
- Inflammatory Mediators in the Oral Fluids and Blood Samples of Type 1 Diabetic Patients, According to Periodontal Status-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).Molecular medicine reports · 2026Review
- Metabolic Syndrome and Periodontitis-From Shared Mechanisms to Interdisciplinary Care: A Narrative Review of Clinical Evidence.Journal of clinical medicine · 2026Review
- Metabolic Risk Signals in Periodontal Clinics: Cross-Sectional Associations of PISA with hs-CRP and HOMA-IR.Diagnostics (Basel, Switzerland) · 2026Article
- GLP-1 Receptor Agonists in Periodontology: Mechanisms, Clinical Evidence, and Implications for Care.Biomolecules · 2026Review
- Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin-Mediated NRF2 Degradation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Melatonin protects liver and periodontal tissues from inflammation exacerbated by metabolic syndrome-periodontitis association.Journal of molecular medicine (Berlin, Germany) · 2026Article
- M2 Macrophages derived exosomes promoted Periodontal ligament stem cells osteogenic differentiation through secreting CCL18.Clinics (Sao Paulo, Brazil) · 2026Article
- Oral Environment of Esophageal Cancer Patients, the Incidence of Complications, and Long-Term Prognoses.Current oncology (Toronto, Ont.) · 2026Review
- Correlation of Oxidative Stress Markers and Nuclear Abnormalities with Clinical Parameters in Individuals with Periodontitis.Dentistry journal · 2026Article
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- From Disease to Illness: Reframing Periodontitis Through an Anthropological Lens.Journal of periodontal research · 2026Review
- Photothermolysis with 1550 nm Fractional Laser Promotes Regeneration of Gingival Mucosa.Bioengineering (Basel, Switzerland) · 2025Article
- Clinical and Radiological Markers of Periodontal Status and Risk of Cognitive Decline and Incident Dementia.Journal of clinical periodontology · 2025Article
- Association between conicity index and prevalence of periodontitis in US adults: the 2009-2014 NHANES cross-sectional study.Scientific reports · 2025Article
- Exploring Putative Causal Associations between Diet and Periodontal Disease Susceptibility.JDR clinical and translational research · 2025Article
- Xianling Gubao capsules improve oral health, alveolar bone defects, and bone density in patients with periodontitis.American journal of translational research · 2025Article
- Serum lipids, oxidative stress, and systemic inflammation mediate the association between circadian syndrome and periodontitis.Frontiers in nutrition · 2025Article
- Periodontal therapy mitigates inflammation via TNF-α reduction and improves glycolipid metabolism in diabetic patients: a cross-sectional cohort study.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease is a complex and progressive chronic inflammatory condition that leads to the loss of alveolar bone and teeth. It has been associated with various systemic diseases, including diabetes mellitus and obesity, among others. Some of these conditions are part of the metabolic syndrome cluster, a group of interconnected systemic diseases that significantly raise the risk of cardiovascular diseases, diabetes mellitus, and stroke. The metabolic syndrome cluster encompasses central obesity, dyslipidemia, insulin resistance, and hypertension. In this review, our objective is to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster. By doing so, we aim to gain insights into the fundamental mechanisms that link each systemic condition with the metabolic syndrome. This deeper understanding of the interplay between these conditions and periodontal disease can pave the way for more effective treatments that take into account the broader impact of managing periodontal disease on the comprehensive treatment of systemic diseases, and vice versa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.