Evidence map›Paper›PMID 37629139›Full record

ArticleInternational journal of molecular sciences2023

Suicide-Gene-Modified Extracellular Vesicles of Human Primary Uveal Melanoma in Future Therapies.

Jana Jakubechova, Bozena Smolkova, Alena Furdova, Lucia Demkova, Ursula Altanerova, Andreas Nicodemou, Tatiana Zeleznikova, Daniela Klimova, Cestmir Altaner

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jana JakubechovaCancer Research Institute, Biomedical Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.
Bozena SmolkovaCancer Research Institute, Biomedical Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.ORCID 0000-0002-4906-5652
Alena FurdovaDepartment of Ophthalmology, Faculty of Medicine, Comenius University, 814 99 Bratislava, Slovakia.ORCID 0000-0001-5689-892X
Lucia DemkovaCancer Research Institute, Biomedical Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.
Ursula AltanerovaStem Cell Preparation Department, St. Elisabeth Cancer Institute, 812 50 Bratislava, Slovakia.
Andreas NicodemouInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 814 99 Bratislava, Slovakia.ORCID 0000-0002-1989-7423
Tatiana ZeleznikovaStem Cell Preparation Department, St. Elisabeth Cancer Institute, 812 50 Bratislava, Slovakia.
Daniela KlimovaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 814 99 Bratislava, Slovakia.
Cestmir AltanerCancer Research Institute, Biomedical Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.ORCID 0000-0001-6998-0885
Cancer Research Institute of the Slovak Academy of Sciences · SKComenius University Bratislava · SK

Funding

Slovak Research and Development Agency APVV-17-0369, APVV-20-0143SPP Foundation 43092023The Ministry of Education, Science, Research and Sport of the Slovak Republic VEGA 1/0395/21
6 · The paper itself

Abstract

Extracellular vesicles secreted from uveal melanoma (UM) cells are involved in the establishment of the premetastatic niche and display transforming potential for the formation of metastases, preferentially in the liver. In this study, we cultivated human primary UM cells and uveal melanoma-associated fibroblasts in vitro to be transduced by infection with a retrovirus containing the suicide gene-fused yeast cytosine deaminase::uracil phospho-ribosyl transferase (

Indexed as

Extracellular VesiclesMelanomaSkin NeoplasmsUveal NeoplasmsAnimalsFlucytosineFluorouracilHumansUveal MelanomaFlucytosineFluorouracilgene-directed enzyme prodrug therapyprimary uveal melanomatherapeutic extracellular vesiclestransduction with suicide gene

Identifiers

PMID37629139
PMCPMC10454466
OpenAlexW4386030225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.