Evidence map›Paper›PMID 37629005›Full record

ArticleInternational journal of molecular sciences2023

The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells.

Valentina La Cognata, Agata Grazia D'Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magrì, Eleonora Aronica, Daniel L Alkon, Velia D'Agata, Sebastiano Cavallaro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Neurodegenerative Disease: From Molecular Basis to Therapy.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Valentina La CognataInstitute for Biomedical Research and Innovation, National Research Council, 95126 Catania, Italy.
Agata Grazia D'AmicoSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Grazia MaugeriSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-0173-4885
Giovanna MorelloInstitute for Biomedical Research and Innovation, National Research Council, 95126 Catania, Italy.
Maria GuarnacciaInstitute for Biomedical Research and Innovation, National Research Council, 95126 Catania, Italy.
Benedetta MagrìSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Eleonora AronicaDepartment of (Neuro) Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 Amsterdam, The Netherlands.ORCID 0000-0002-3542-3770
Daniel L AlkonSynaptogenix, Inc., New York, NY 10036, USA.
Velia D'AgataSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1114-8265
Sebastiano CavallaroInstitute for Biomedical Research and Innovation, National Research Council, 95126 Catania, Italy.ORCID 0000-0001-7590-1792
Institute for Biomedical Research and Innovation · ITUniversity of Catania · ITAmsterdam Neuroscience · NL

Funding

IRIB-CNR DSB.AD007.304
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, characterized by a progressive depletion of upper and lower motor neurons (MNs) in the brain and spinal cord. The aberrant regulation of several PKC-mediated signal transduction pathways in ALS has been characterized so far, describing either impaired expression or altered activity of single PKC isozymes (α, β, ζ and δ). Here, we detailed the distribution and cellular localization of the ε-isozyme of protein kinase C (PKCε) in human postmortem motor cortex specimens and reported a significant decrease in both PKCε mRNA (

Indexed as

Amyotrophic Lateral SclerosisMotor CortexNeurodegenerative DiseasesBryostatinsHumansIsoenzymesMotor NeuronsProtein Kinase C-epsilonSuperoxide Dismutase-1bryostatin 1BryostatinsIsoenzymesProtein Kinase C-epsilonSOD1 protein, humanSuperoxide Dismutase-1amyotrophic lateral sclerosisBryostatin-1neurodegenerationPKCεPRKCE

Identifiers

PMID37629005
PMCPMC10454105
OpenAlexW4385835406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.