Evidence map›Paper›PMID 37628964›Full record

ArticleInternational journal of molecular sciences2023

Probing the Effect of Acidosis on Tether-Mode Mechanotransduction of Proprioceptors.

Yuan-Ren Cheng, Chih-Hung Chi, Cheng-Han Lee, Shing-Hong Lin, Ming-Yuan Min, Chih-Cheng Chen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. CaBiomolecules · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuan-Ren ChengDepartment of Life Science, National Taiwan University, Taipei 10090, Taiwan.
Chih-Hung ChiInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-1791-4370
Cheng-Han LeeInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-3642-4115
Shing-Hong LinInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Ming-Yuan MinDepartment of Life Science, National Taiwan University, Taipei 10090, Taiwan.
Chih-Cheng ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-4768-5660

Funding

Academia Sinica AS-IA111-L06National Science and Technology Council of Taiwan NSTC112-2321-B-001-009
6 · The paper itself

Abstract

Proprioceptors are low-threshold mechanoreceptors involved in perceiving body position and strain bearing. However, the physiological response of proprioceptors to fatigue- and muscle-acidosis-related disturbances remains unknown. Here, we employed whole-cell patch-clamp recordings to probe the effect of mild acidosis on the mechanosensitivity of the proprioceptive neurons of dorsal root ganglia (DRG) in mice. We cultured neurite-bearing parvalbumin-positive (Pv+) DRG neurons on a laminin-coated elastic substrate and examined mechanically activated currents induced through substrate deformation-driven neurite stretch (SDNS). The SDNS-induced inward currents (

Indexed as

AcidosisMechanotransduction, CellularAnimalsMechanoreceptorsMiceNeuritesParvalbuminsParvalbuminsacidosisAPETx2ASIC3mechanotransductionproprioceptorsSDNS

Identifiers

PMID37628964
PMCPMC10454156

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.