Evidence map›Paper›PMID 37628941›Full record

ArticleInternational journal of molecular sciences2023

Expression Levels of the

Qingqing Gu, Buyan-Ochir Orgil, Akhilesh Kumar Bajpai, Yufeng Chen, David G Ashbrook, Athena Starlard-Davenport, Jeffrey A Towbin, Djamel Lebeche, Enkhsaikhan Purevjav, Hongzhuan Sheng and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecular Pathways and Animal Models of Cardiomyopathies.Advances in experimental medicine and biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Qingqing GuDepartment of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, China.ORCID 0000-0003-3409-8969
Buyan-Ochir OrgilThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Akhilesh Kumar BajpaiDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Yufeng ChenDepartment of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
David G AshbrookDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-7397-8910
Athena Starlard-DavenportDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-8938-237X
Jeffrey A TowbinThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.ORCID 0000-0002-4182-2786
Djamel LebecheDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-7911-2923
Enkhsaikhan PurevjavThe Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.ORCID 0000-0001-6188-7176
Hongzhuan ShengDepartment of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
University of Tennessee Health Science Center · USNantong University · CNSt. Jude Children's Research Hospital · US

Funding

Discovery of modifier genes in cardiomyopathyR01HL151438 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, PUREVJAV, ENKHSAIKHAN · 2020 to 2023
$2.5M
Genetic Modulation of Hypertrophic Cardiomyopathy SeverityR01HL128350 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, SUN, YAO · 2016 to 2019
$2.0M
National Institute of Health R01HL151438, R01HL128350NHLBI NIH HHS R01 HL128350NHLBI NIH HHS R01 HL151438
6 · The paper itself

Abstract

backgroundTroponin-I interacting kinase encoded by the

methodsWe performed cardiac gene expression, whole genome sequencing (WGS), and cardiac function analysis in 40 strains of BXD recombinant inbred mice derived from C57BL/6J (B6) and DBA/2J (D2) strains. Expression quantitative trait loci (eQTLs) mapping and gene enrichment analysis was performed, followed by validation of candidate

resultsWGS identified compound splicing and missense T659I

conclusionsCompound splicing and T659I

Indexed as

Carbohydrate MetabolismMyocytes, CardiacAnimalsGlucoseMiceMice, Inbred C57BLMice, Inbred DBAProtein Serine-Threonine KinasesGlucoseProtein Serine-Threonine KinasesTnni3k protein, mouseBXD familycardiac physiologyglucose metabolismsystems geneticsTnni3k

Identifiers

PMID37628941
PMCPMC10454158
OpenAlexW4385805792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.