ReviewInternational journal of molecular sciences2023
Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Clinical evaluation of platelet-rich plasma therapy for osteonecrosis of the femoral head: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Outcome Analysis of Leukocyte-Rich Platelet-Rich Plasma, Leukocyte-Poor Platelet-Rich Plasma, and Injectable Platelet-Rich Fibrin in the Management of Chronic Plantar Fasciitis: A Prospective Comparative Study.Journal of orthopaedic case reports · 2026Article
- Multivariate Analysis of Inflammatory and Regenerative Mediators in an In Vitro Canine Osteoarthritis System Treated with Platelet Gel Supernatants.Gels (Basel, Switzerland) · 2026Article
- Comparison of the effects of injectable platelet-rich fibrin and concentrated growth factor on tendon-bone interface healing in the rabbit rotator cuff tear model.Acta orthopaedica et traumatologica turcica · 2026Article
- The Effect of Platelet-Rich Fibrin on Block, Crushed and Diced Cartilage.Aesthetic plastic surgery · 2026Article
- Biologic Augmentation for Meniscus Repair: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- The evolving landscape of minimally invasive procedures in musculoskeletal diseases-Part II.Frontiers in medicine · 2026Review
- Applications of leukocyte platelet-rich fibrin in oral and maxillofacial surgery: case series.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Article
- Engineering Regenerative Fibrin Scaffold from Balanced Protein-Concentrate Plasma: Structural and Biochemical Characterization.Pharmaceutics · 2025Article
- Efficacy and Safety of Platelet-Rich Plasma for Patients With Meniscal Injury: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Orthopaedic journal of sports medicine · 2025Review
- Biologic Augmentation in Anterior Cruciate Ligament Reconstruction and Beyond: A Review of PRP and BMAC.Journal of clinical medicine · 2025Review
- Cartilage repair: unleashing PRP's potential in organoid models.Cytotechnology · 2025Review
- The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?Current issues in molecular biology · 2025Review
- Comparative analysis of cytokine profiles in canine injectable platelet-rich fibrin and platelet-rich plasma.International journal of veterinary science and medicine · 2025Article
- Trends and Collaborations in Mesenchymal Stem Cell Research Applied to Animal Models of Osteoarthritis: A Bibliometric Analysis (2015-2024).Veterinary medicine international · 2025Review
- Platelet-rich fibrin in the management of oral mucosal lesions: a scoping review.BMC oral health · 2024Article
- Developing fibrin-based biomaterials/scaffolds in tissue engineering.Bioactive materials · 2024Review
- Human versus Rat PRF on Collagen Membranes: A Pilot Study of Mineralization in Rat Calvaria Defect Model.Bioengineering (Basel, Switzerland) · 2024Article
- Clinical observation of ultraviolet therapy combined with autologous platelet-rich plasma in the treatment of chronic refractory wounds.International wound journal · 2024Article
- Autologous leucocyte and platelet rich in fibrin (L-PRF) - is it a competitive solution for bone augmentation in maxillary sinus lift? A 6-month radiological comparison between xenografts and L-PRF.Medicine and pharmacy reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
In recent years, several types of platelet concentrates have been investigated and applied in many fields, particularly in the musculoskeletal system. Platelet-rich fibrin (PRF) is an autologous biomaterial, a second-generation platelet concentrate containing platelets and growth factors in the form of fibrin membranes prepared from the blood of patients without additives. During tissue regeneration, platelet concentrates contain a higher percentage of leukocytes and a flexible fibrin net as a scaffold to improve cell migration in angiogenic, osteogenic, and antibacterial capacities during tissue regeneration. PRF enables the release of molecules over a longer period, which promotes tissue healing and regeneration. The potential of PRF to simulate the physiology and immunology of wound healing is also due to the high concentrations of released growth factors and anti-inflammatory cytokines that stimulate vessel formation, cell proliferation, and differentiation. These products have been used safely in clinical applications because of their autologous origin and minimally invasive nature. We focused on a narrative review of PRF therapy and its effects on musculoskeletal, oral, and maxillofacial surgeries and dermatology. We explored the components leading to the biological activity and the published preclinical and clinical research that supports its application in musculoskeletal therapy. The research generally supports the use of PRF as an adjuvant for various chronic muscle, cartilage, and tendon injuries. Further clinical trials are needed to prove the benefits of utilizing the potential of PRF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.