Evidence map›Paper›PMID 37628729›Full record

ArticleInternational journal of molecular sciences2023

Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype.

Eric W J Gates, Nicholas D Calvert, Nicholas J Cundy, Federica Brugnoli, Pauline Navals, Alexia Kirby, Nicoletta Bianchi, Gautam Adhikary, Adam J Shuhendler, Richard L Eckert and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Role of Transglutaminase 2 in Cancer: An Update.International journal of molecular sciences · 2024
    Review
  6. Preclinical evaluation of anEJNMMI radiopharmacy and chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Eric W J GatesDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0003-3381-2200
Nicholas D CalvertDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0002-6637-9063
Nicholas J CundyDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0001-6783-5422
Federica BrugnoliDepartment of Translational Medicine, University of Ferrara, 44021 Ferrara, Italy.
Pauline NavalsDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0002-2703-429X
Alexia KirbyDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Nicoletta BianchiDepartment of Translational Medicine, University of Ferrara, 44021 Ferrara, Italy.ORCID 0000-0001-9280-6017
Gautam AdhikaryDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Adam J ShuhendlerDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Richard L EckertDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jeffrey W KeillorDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.ORCID 0000-0002-8133-6862
University of Ottawa · CAUniversity of Ferrara · ITUniversity of Maryland, Baltimore · US

Funding

Canada Research Chairs 950-230735Natural Sciences and Engineering Research Council RGPIN-2019-05893
6 · The paper itself

Abstract

Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a transamidase by crosslinking two substrates through formation of an N

Indexed as

NeoplasmsProtein Glutamine gamma Glutamyltransferase 2Fluorescent DyesHumansPhenotypeTransglutaminasesFluorescent DyesProtein Glutamine gamma Glutamyltransferase 2Transglutaminasescancercell impermeablechemical labelfluorescence microscopyfluorescent probeinhibitiontransglutaminase 2

Identifiers

PMID37628729
PMCPMC10454375
OpenAlexW4385658020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.