Evidence map›Paper›PMID 37628726›Full record

ArticleInternational journal of molecular sciences2023

Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State.

Bengt Svensson, Florentin R Nitu, Robyn T Rebbeck, Lindsey M McGurran, Tetsuro Oda, David D Thomas, Donald M Bers, Razvan L Cornea

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bengt SvenssonDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-3932-2376
Florentin R NituDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9768-6333
Robyn T RebbeckDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-3840-2286
Lindsey M McGurranDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Tetsuro OdaDepartment of Pharmacology, University of California, Davis, CA 95616, USA.
David D ThomasDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8822-2040
Donald M BersDepartment of Pharmacology, University of California, Davis, CA 95616, USA.ORCID 0000-0002-2237-9483
Razvan L CorneaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5739-0992
University of Minnesota · USUniversity of California, Davis · US

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
Structural Dynamics of Muscle Calcium ATPase RegulationR01GM027906 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 1985 to 2016
$8.6M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
Structural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2M
Site-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5M
Calcium Pump Activators for Heart Failure TherapyR01HL129814 · NHLBI · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2015 to 2018
$3.2M
Multidisciplinary Training in Cardiovascular ResearchT32HL069764 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BACHE, ROBERT JAMES · 2003 to 2013
$2.8M
Skeletal muscle protein structural dynamics and function drive applications to drug discoveryR01AR082533 · NIAMS · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE, Robyn T Rebbeck · 2023 to 2026
$2.5M
NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL129814NHLBI NIH HHS R01 HL139065NHLBI NIH HHS R01 HL142282NHLBI NIH HHS T32 HL069764NIAMS NIH HHS R01 AR082533NIA NIH HHS R37 AG026160NIGMS NIH HHS R01 GM027906NIH HHS R01GM027906NIH HHS R01HL092097NIH HHS R01HL129814NIH HHS R37AG026160NIH HHS T32HL069764
6 · The paper itself

Abstract

Ca

Indexed as

Fluorescence Resonance Energy TransferRyanodine Receptor Calcium Release ChannelBinding SitesDrug Delivery SystemsRyanodine Receptor Calcium Release Channelcalcium release channelcalmodulinFKBP12.6fluorescence lifetimeFRETsarcoplasmic reticulum

Identifiers

PMID37628726
PMCPMC10454150
OpenAlexW4385658004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.