ArticleGenes2023
Spontaneous Emergence of Multicellular Heritability.
Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Review
- Review
- Plasticity and the evolution of group-level regulation of cellular differentiation in the volvocine algae.Proceedings. Biological sciences · 2025Article
- Oxygen-binding proteins aid oxygen diffusion to enhance fitness of a yeast model of multicellularity.PLoS biology · 2025Article
- Emergence and maintenance of stable coexistence during a long-term multicellular evolution experiment.Nature ecology & evolution · 2024Article
- Proteostatic tuning underpins the evolution of novel multicellular traits.Science advances · 2024Article
- Examining the role of oxygen-binding proteins on the early evolution of multicellularity.bioRxiv : the preprint server for biology · 2023Article
- Article
- De novo evolution of macroscopic multicellularity.Nature · 2023Article
- Varied solutions to multicellularity: The biophysical and evolutionary consequences of diverse intercellular bonds.Biophysics reviews · 2022Review
- Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law.eLife · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The major transitions in evolution include events and processes that result in the emergence of new levels of biological individuality. For collectives to undergo Darwinian evolution, their traits must be heritable, but the emergence of higher-level heritability is poorly understood and has long been considered a stumbling block for nascent evolutionary transitions. Using analytical models, synthetic biology, and biologically-informed simulations, we explored the emergence of trait heritability during the evolution of multicellularity. Prior work on the evolution of multicellularity has asserted that substantial collective-level trait heritability either emerges only late in the transition or requires some evolutionary change subsequent to the formation of clonal multicellular groups. In a prior analytical model, we showed that collective-level heritability not only exists but is usually more heritable than the underlying cell-level trait upon which it is based, as soon as multicellular groups form. Here, we show that key assumptions and predictions of that model are borne out in a real engineered biological system, with important implications for the emergence of collective-level heritability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.