Evidence map›Paper›PMID 37628675›Full record

ArticleGenes2023

Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy.

Veronica Feijoli Santiago, Jamille Gregorio Dombrowski, Rebeca Kawahara, Livia Rosa-Fernandes, Simon Ngao Mule, Oscar Murillo, Thais Viggiani Santana, Joao Victor Paccini Coutinho, Janaina Macedo-da-Silva, Lucas Cardoso Lazari and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Plasma protein biomarkers ofFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 4 countries.

Veronica Feijoli SantiagoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-0052-9532
Jamille Gregorio DombrowskiDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-1863-1914
Rebeca KawaharaDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Livia Rosa-FernandesDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-1612-1950
Simon Ngao MuleDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Oscar MurilloDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-1204-7984
Thais Viggiani SantanaDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-2499-3591
Joao Victor Paccini CoutinhoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Janaina Macedo-da-SilvaDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Lucas Cardoso LazariDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Erika Paula Machado PeixotoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Marcel Ivan RamirezCell Biology Laboratory, Carlos Chagas Institute, Fiocruz, Curitiba 81350-010, Brazil.
Martin R LarsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark.
Cláudio Romero Farias MarinhoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-1227-3845
Giuseppe PalmisanoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Universidade de São Paulo · BRFundação Carlos Chagas · BRUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria in pregnancy (MiP) is a public health problem in malaria-endemic areas, contributing to detrimental outcomes for both mother and fetus. Primigravida and second-time mothers are most affected by severe anemia complications and babies with low birth weight compared to multigravida women. Infected erythrocytes (IE) reach the placenta, activating the immune response by placental monocyte infiltration and inflammation. However, specific markers of MiP result in poor outcomes, such as low birth weight, and intrauterine growth restriction for babies and maternal anemia in women infected with

Indexed as

MalariaPlacentaAnimalsBiomarkersComplement ActivationFemaleHumansInfantInfant, NewbornMiceMice, Inbred CBAPregnancyBiomarkersbiomarkerscomplement systemmalariamalaria in pregnancyplasma proteomicsPlasmodium bergheiPlasmodium falciparum

Identifiers

PMID37628675
PMCPMC10454407
OpenAlexW4385835088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.